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Clinical Application of a Low-Dose CBCT AI Model

RecruitingNAAges 18 Years - anyAllUnion Hospital, Tongji Medical College, Huazhong …
NCT07845929 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Cone Beam CT (CBCT) is an imaging modality used in interventional digital subtraction angiography (DSA). It produces three-dimensional images via cone-beam X-ray scanning and computer reconstruction. Clinically, CBCT guides puncture for pulmonary and hepatic lesions and evaluates post-intervention outcomes in liver cancer and cerebrovascular diseases. However, CBCT-guided interventions carry high patient radiation exposure; dose reduction often degrades image quality and impairs procedural results. Studies report that each 100 mGy radiation increment elevates cancer risk by 1.96-fold. Artificial intelligence enables low-dose CBCT. Our prior DeepPriorCBCT model embedded anatomical priors using neural discrete representation learning, reducing thoracic CBCT dose to one-sixth of routine protocols while preserving image quality. We further developed DeepPriorCBCT-V2 using 55 000 pre-reconst

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥18 years. * Requires CBCT-guided interventional treatment or surgery (e.g., cerebral angiography, lung puncture biopsy, hepatic artery chemoembolization, or percutaneous liver biopsy) and meets operational indications. * Can understand the study's purpose, procedures, potential risks, and benefits, and voluntarily signs a written informed consent form. Exclusion Criteria: * History of high-dose radiation exams or treatments. * Known allergies or severe adverse reactions to iodine contrast agents or other relevant medications. * Pregnant or breastfeeding women. * Severe comorbidities or chronic diseases (e.g., severe diabetes, renal insufficiency). * Severe mental illness or cognitive impairment preventing understanding of the study procedures or providing informed consent. ⑥ Participants are not suitable for the trial per investigator's opinion.
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What it tests

  • DeepPriorCBCT-V2
  • Clinical standard protocol (Full-radiation-dose CBCT)
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Where

5 sites
The First Affiliated Hospital of University of Science and Technology of China
Hefei, China
Wuhan Union Hospital
Wuhan, China
Wuhan Union Jinyin Lake Hospital
Wuhan, China
Wuhan Union West Hospital
Wuhan, China
Zhongda Hospital, Medical School, Southeast University
Nanjing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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