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Esmolol Versus Dexmedetomidine for Opioid-sparing in Laparoscopic Gynecological Surgery

RecruitingNAAges 20 Years - 70 YearsFemaleVasiliki Samartzi
NCT07846722 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

The aim of this study is to investigate and compare the effects of a continuous infusion of low-dose esmolol and dexmedetomidine versus placebo on intraoperative and postoperative opioid consumption and analgesic efficacy in patients undergoing laparoscopic hysterectomy.

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * adult patients * American Society of Anesthesiologists (ASA) classification I-II * Laparoscopic hysterectomy Exclusion Criteria: * body mass index (BMI) \>35 kg/m2 * ฮฒ-blocker administration preoperatively * systematic use of analgesic agents preoperatively * chronic pain syndromes preoperatively * neurological or psychiatric disease on treatment * pregnancy * severe hepatic or renal disease * history of cardiovascular diseases/ arrhythmias/ conduction abnormalities * hemodynamic instability * patients with a known malignancy or undergoing surgery for oncological reasons * known allergy to a local anesthetic * drug or alcohol abuse * language or communication barriers * lack of informed consent
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What it tests

  • Esmolol hydrochloride
  • Dexmedetomidine
  • Normal (0.9%) saline
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Where

1 site
"Alexandra" General Hospital
Athens, Greece
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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