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Risk of Cervical Cancer Following Incident, Persistent and History-unknown HPV Detection

Recruitingn/aAges 22 Years - 70 YearsFemaleKarolinska Institutet
NCT07850128 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this register-based retrospective observational study is to understand the risk of cervical cancer following incident, persistent and history-unknown HPV detection by HPV genotype in healthy women participating in HPV-based cervical screening. The main questions it aims to answer are: 1. Whether an incident HPV detection with certain HPV genotypes has low risk of cervical cancer in 3 to 5 years thus does not need further clinical assessment before the next screening test? 2. How risky a persistent HPV detection is, and whether persistent detection of any high-risk HPV genotype warrant immediate clinical assessment? 3. How risky a HPV detection is, if no previous HPV test result is available? As being a register-based retrospective observational study, study subjects will not be asked to do any specific task for this study.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Women living in the Great Stockholm Region in Sweden, at cervical screening ages (age 22-70 years), and having had an HPV positive result in primary HPV test during 2014-2023 Exclusion Criteria: * Women without valid personal identity number in the population registry
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What it tests

  • No Intervention: Observational Cohort
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Where

1 site
Centre for Cervical Cancer Elimination, Department of Clinical Science, Intervention and Technology, Karolinska Institutet
Stockholm, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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