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โ† Trials
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A Study to Assess the Efficacy and Safety of RO7965032 in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration

RecruitingPhase 2Ages 50 Years - anyAllGenentech, Inc.
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In plain words

What the trial is, and whether it could suit you

This study will assess the safety and efficacy of RO7965032 to address a significant unmet medical need in participants with geographic atrophy (GA) secondary to age-related macular degeneration (AMD)

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: Ocular Inclusion Criteria for the Study Eye * BCVA score of \>= 35 letters using the ETDRS VA chart at a starting distance of 4 meters * Lesions may be either extrafoveal or subfoveal Ocular Inclusion Criteria for Both Eyes * Sufficiently clear ocular media, adequate pupillary dilation, and fixation to permit quality fundus imaging * Well-demarcated GA secondary to AMD Exclusion Criteria: General Exclusion Criteria - History of hypersensitivity, a severe allergic reaction or anaphylactic reaction to any component of the investigational drug injection Ocular Exclusion Criteria for the Study Eye * History of diabetic macular edema (DME), retinal vein occlusion, corneal transplant, retinal detachment, Stage 3 or 4 macular hole, optic neuropathy, or retinal dystrophy * Current or prior history of central serous retinopathy * Aphakia or absence of the posterior capsule in the study eye Ocular Exclusion Criteria for the Non-Study Eye \- Non-functioning non-study eye defined as either BCVA of hand motion or worse or no physical presence of non-study eye (i.e., monocular) Ocular Exclusion Criteria for Either Eye * Proliferative diabetic retinopathy * History of recurrent infectious or inflammatory ocular disease * Current or prior history of choroidal neovascularization (CNV) in either eye * Active, infectious conjunctivitis, keratitis, scleritis, or endophthalmitis in either eye Other protocol-defined inclusion/exclusion criteria may apply
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What it tests

  • RO7965032
  • Placebo
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Where

5 sites
Bay Area Retina Specialists Medical Group - Vestrum - PPDS
Walnut Creek, United States
Piedmont Retina Specialists
Winston-Salem, United States
Erie Retina Research
Erie, United States
Texas Retina Associates - Arlington
Arlington, United States
Piedmont Eye Center
Lynchburg, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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