💬In plain words
What the trial is, and whether it could suit you
To date, no rigorous randomized controlled trials have demonstrated a protective effect of daily moderate walnut consumption on kidney function or chronic kidney disease (CKD) progression in individuals with CKD.
Objective: To determine the effect of walnut supplementation (30 g/day of raw walnuts) within a Mediterranean diet (MedDiet) based dietary counseling program, compared with the same MedDiet counseling program without walnut supplementation, on kidney function, CKD progression and regression, and classical and emerging cardiovascular risk markers in individuals with CKD. Secondary objectives focus on assessing whether regular walnut consumption as a healthy snack has a positive impact on inflammation, oxidative stress, endothelial dysfunction, and intestinal dysbiosis, conditions intrinsically linked to CKD that play a pathophysiological role in promoting/exacerbating its progre
Sign in to get the eligibility rules as simple questions to take to your doctor.
📋 Eligibility rules (as published)
Inclusion Criteria:
* Men and women with stable mild to moderate chronic kidney disease \[CKD\] (stage G3a-b (estimated glomerular filtration rate \[eGFR\] 30-\<60mL/min/1.73 m²) and albuminuria stages A1-3 (UACR from \< 30mg/g to ≥ 300 mg/g))
* 45-75 years old at screening
* Overweight/obesity (Body Mass Index \[BMI\] ≥25 and ≤40 kg/m²)
* Meet at least one of the following conditions:
(i) Systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg, or use of antihypertensive agents (ii) Triglycerides ≥150 mg/dL, LDL cholesterol ≥160 mg/dL, HDL cholesterol ≤40 mg/dL in men or ≤50 mg/dL in women, or use of lipid-modifying medication (iii) Prediabetes or type 2 diabetes according to the American Diabetes Association (ADA) Standards, or use of glucose-lowering medication.
Exclusion Criteria:
* Inability to give written informed consent
* CKD caused by polycystic kidney disease, chronic pyelonephritis, and renal dysplasia
* CKD on renal replacement therapy (hemodialysis, peritoneal dialysis, and kidney transplant recipients)
* Acute exacerbation of CKD, whether due to extrarenal causes (decompensated heart failure, infectious disease or sepsis, surgical intervention) or due to an outbreak of underlying glomerular or systemic renal pathology, with changes in treatment in the last 2 months.
* Nut allergy
* Alcoholism (\>50 g/day) or drug abuse
* Treatment with immunosuppressant drugs or cytotoxic agents
* Any other medical condition that interferes with the completion of the protocol (pregnancy/breastfeeding, history of inflammatory bowel disease, liver failure, cancer or active neoplasms, psychiatric problems)
* Institutionalization of the participant.
Unit for Public Health and Nutritional Epidemiology, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili
Reus, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
HealthTeky