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Cognitive Neurocomputational Task Reliability & Clinical Applications Consortium (CNTRACS): Study 1

RecruitingNAAges 18 Years - 59 YearsAllWashington University School of Medicine
NCT07853807 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In Study 1, investigators will test the ability of each of the seven paradigms to differentiate between schizophrenia (SZ)/schizoaffective disorder (SZA) and matched healthy control subjects (HC) and to predict individual differences in clinical measures of hallucinations and delusions (as well as measures of function). Investigators will also directly compare the tasks in terms of predictive ability and psychometric properties and determine whether the tasks share variance or explain unique variance. This will include determining whether hallucinations and delusions are best explained by separate underlying processes or by a single process. Investigators will also test whether the model-based parameters from these studies are more precise and sensitive than standard behavioral methods for assessing deficits across psychotic disorders and for predicting hallucinations and delusions (Aim

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📋 Eligibility rules (as published)
Inclusion Criteria: General Inclusion 1. age 18 to 59 2. no substance disorder in past six months (confirmed with urine drug screens and breathalyzers); 3. no clinically significant head injury or neurological disease. 4. Wechsler Test of Adult Reading (WTAR) score =16+. Group Specific Criteria: Schizophrenia/Schizoaffective Disorder (SZ): 1. Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) diagnosis of schizophrenia or schizoaffective; 2. no medication changes in prior month or anticipated in the next month or not taking medications 3. outpatient or partial hospital if unmedicated Healthy Controls (HC): 1. no Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) Psychosis or Bipolar Disorder; 2. no family history of psychosis or bipolar Exclusion Criteria: Healthy Controls (HC): 1. Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) Psychosis or Bipolar Disorder diagnosis 2. Family history of psychosis or bipolar Schizophrenia/Schizoaffective Disorder (SZ/SZA): additional exclusion criteria for the unmedicated individuals are: 1. not in acute exacerbation requiring immediate hospitalization or treatment 2. self-reported medication non-compliance for at least the four previous weeks 3)never having started medications
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What it tests

  • Motion Perception Task
  • Sine Wave Speech Task
  • Volatility Task
  • Choice Probabilistic Reversal Task
  • Kamin Blocking Task
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Where

5 sites
University of California, Irvine
Irvine, United States
The University of Chicago
Chicago, United States
University of Maryland, Baltimore
Baltimore, United States
University of Minnesota
Minneapolis, United States
Washington University
St Louis, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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