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Clinical and Radiographic Evaluation of UV-Treated Dental Implants With or Without Melatonin in the Upper Posterior Jaw

RecruitingNAAges 18 Years - 60 YearsAllMansoura University
NCT07853976 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to evaluate and compare the clinical and radiographic outcomes of using photofunctionalized (UV-treated) dental implants with or without the application of melatonin hormone in the posterior maxilla (upper back jaw). The posterior maxilla is known to have lower bone quality, which can negatively affect the primary and secondary stability of dental implants,. UV photofunctionalization is a method that modifies the titanium surface of the implant, changing it from hydrophobic (water-repelling) to superhydrophilic (water-attracting). This enhancement aims to accelerate protein adsorption and promote bone-building cells (osteoblasts). On the other hand, melatonin acts as an anti-inflammatory and antioxidant agent that stimulates bone formation and reduces bone resorption. A total of 21 dental implants will be placed in patients requiring tooth replacement in th

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged between 18 and 60 years old. * Patients seeking replacement of missed single or multiple teeth in the posterior maxilla. * Sufficient bone volume (height and width) to accommodate dental implant placement without major bone grafting. * Good oral hygiene and motivated patients. * Systemically healthy patients with no contraindications for minor oral surgery. Exclusion Criteria: * Patients with uncontrolled systemic diseases * Patients who received radiation therapy in the head and neck region within the last 5 years. * Heavy smokers (more than 10 cigarettes per day). * Patients with active periodontal disease or poor oral hygiene. * Pregnant or lactating females. * Parafunctional habits such as severe bruxism or clenching.
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What it tests

  • UV-Photofunctionalized Dental Implant
  • Conventional Dental Implant
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Where

1 site
Faculty of Dentistry, Mansoura University
Al Mansurah, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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