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Shrimp Sensitization and Allergy Among Patients With Edible Insect Allergy

RecruitingNAAges 7 Years - anyAllMahidol University
NCT07857187 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to determine the prevalence of shrimp sensitization and clinical shrimp allergy among patients aged ≥7 years with confirmed allergy to edible insects, including silkworm, bamboo worm, and palm weevil. Participants undergo skin prick testing, specific IgE testing, ALEX2, immunoblot analysis, and risk-based oral food challenges to assess clinical cross-reactivity between edible insects and white shrimp and to help avoid unnecessary shrimp restriction.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged 7 years or older with a history of allergy to one or more of the following edible insects: silkworm, bamboo worm, or palm weevil. * Patients with a history of an acute allergic reaction to silkworm, bamboo worm, or sago palm weevil who meet at least one of the following criteria: 1. Development of clinical symptoms consistent with an acute allergic reaction within 2 hours after ingestion of the implicated edible insect, with evidence of sensitization confirmed by a positive skin prick test (SPT) to that edible insect; or 2. A positive oral food challenge (OFC) to the edible insect previously associated with allergic symptoms (silkworm, bamboo worm, or sago palm weevil). Exclusion Criteria: * Scombroidosis (histamine fish poisoning). * Currently receiving allergen immunotherapy. * Unable to comply with the study follow-up schedule. * Uncontrolled or severe asthma. * Cardiovascular disease. * Current use of beta-blockers, angiotensin-converting enzyme inhibitors (ACEIs), or angiotensin receptor blockers (ARBs). * Developmental delay or intellectual disability.
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What it tests

  • Edible Insect Oral Food Challenge
  • White Shrimp Oral Food Challenge
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Where

1 site
Siriraj hospital
Bangkok, Thailand
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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