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Transcutaneous Auricular Vagus Nerve Stimulation-Enriched Rehabilitation in Individuals With Lipedema

RecruitingNAAges 18 Years - 65 YearsFemaleIstanbul University - Cerrahpasa
NCT07857499 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Lipedema is a chronic inflammatory disorder of adipose tissue that predominantly affects women and is associated with estrogen-mediated mechanisms. \[1\] Conservative physiotherapy approaches, including exercise, compression therapy, complex decongestive therapy (CDT), and behavioral interventions, are recommended for the management of lipedema. \[2,3\] Transcutaneous auricular vagus nerve stimulation (taVNS) is a neuromodulation method that may reduce pro-inflammatory cytokines through the cholinergic anti-inflammatory pathway and exert metabolic and autonomic regulatory effects. \[4\] These effects suggest that taVNS may serve as a complementary intervention to exercise and conservative physiotherapy approaches in the management of chronic low-grade inflammation, one of the pathophysiological components of lipedema. In light of this evidence, the aim of this study is to comparatively i

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📋 Eligibility rules (as published)
Inclusion Criteria: * Female participants aged 18-65 years. * Clinical diagnosis of lipedema confirmed by a specialist physician. * Bilateral and symmetrical disproportionate adipose tissue accumulation in the lower extremities. * Pain or tenderness on pressure in the affected areas. * Negative Stemmer's sign. * Willingness to participate in the study and provision of written informed consent. Exclusion Criteria: * Secondary or iatrogenic obesity due to endocrine disorders or medication use. * Body weight change greater than 10% within the previous six months. * Initiation or modification of estrogen-progestin therapy within the previous two months.
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What it tests

  • Active taVNS
  • Sham taVNS
  • Aerobic Exercise
  • Complex Decongestive Therapy (CDT)
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Where

1 site
Bezmialem Vakif University
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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