Metabolic and Immunologic Biomarkers in Chronic Rhinosinusitis With Nasal Polyps

CRSwNP Group Inclusion Criteria: * Age 18 years or older * Diagnosis of chronic rhinosinusitis with nasal polyps at the Otorhinolaryngology outpatient clinic * Diagnosis of nasal polyposis confirmed by histopathological examination of a punch biopsy or surgical specimen * No condition preventing the collection of tissue and peripheral blood samples within the scope of the study Exclusion Criteria: * Acute upper respiratory tract infection or acute rhinosinusitis * History of systemic inflammatory or autoimmune disease * History of malignancy or active malignant disease * Immunodeficiency or use of immunosuppressive therapy * Use of systemic corticosteroids, biologic agents or immunomodulatory therapy within the last 4 weeks * Use of antibiotics for an acute infection within the last 4 weeks * Pregnancy or breastfeeding * Presence of an additional systemic disease severe enough to prevent participation in the study Control Group Inclusion Criteria: * Age 18 years or older * No history of nasal polyposis or chronic rhinosinusitis * Scheduled for septoplasty, rhinoplasty or similar nasal surgery for reasons other than nasal polyps * Collection of a healthy nasal mucosa biopsy during surgery poses no additional risk Exclusion Criteria: \* Same exclusion criteria as the CRSwNP group