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Dual Trigger VS HCG Trigger for Final Oocyte Maturation in Normal Responders

RecruitingNAAges 20 Years - 40 YearsFemaleAl-Azhar University
NCT07861399 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

To compare the embryological and reproductive outcomes of dual trigger versus conventional hCG trigger for final oocyte maturation in normal responder patients undergoing ICSI cycles.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Women aged 20-40 years. * Body mass index (BMI) between 18 and 30 kg/m². * Undergoing ICSI treatment using a GnRH antagonist protocol. * Normal ovarian reserve and expected normal ovarian response. * AMH between 1.2 - 3.5 ng/ml * AFC 7-15 follicle. * First or second ICSI cycle. Exclusion Criteria: * Poor ovarian response (Bologna/POSEIDON criteria) * High ovarian response with a risk of ovarian hyperstimulation syndrome (OHSS) AMH \> 3.5 ng/ml or AFC \> 15 follicle. * Polycystic ovary syndrome (PCOS). * Serum E2 level \> 3500 pg/ml at day of triggering. * Endocrine disorders including diabetes mellitus, thyroid dysfunction, hyperprolactinemia, congenital adrenal hyperplasia, or Cushing syndrome. * Congenital uterine abnormalities. * Severe systemic diseases affecting fertility outcomes.
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What it tests

  • Dual trigger (human chorionic gonadotropin plus GnRH-agonist)
  • hCG trigger
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Where

1 site
ART Unit, International Islamic Center for Population Studies and Research, Al-Azhar University
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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