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Serum Endogenous Estrogens, Estrogen Receptors, and Sirtuin-1 and -3 After Resveratrol Supplementation

RecruitingNAAges 45 Years - 70 YearsFemaleInCor Heart Institute
NCT07865377 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Atherosclerotic coronary artery disease (CAD) is a leading cause of mortality among postmenopausal women. Resveratrol, a phenolic compound with antioxidant properties, may influence lipid metabolism, endothelial function, and platelet aggregation, while sirtuin-1 and sirtuin-3 regulate metabolic and hormonal responses to nutritional stimuli. This randomized, double-blind, placebo-controlled trial evaluates the effects of trans-resveratrol supplementation (1000 mg/day) versus placebo, over 90 days, on serum estradiol and estrone levels, gene expression of estrogen receptors alpha and beta, and sirtuins 1 and 3 in 80 postmenopausal women with CAD. Findings may inform therapeutic strategies for postmenopausal women with chronic coronary disease.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Postmenopausal women; * Diagnosed coronary artery disease; * Stable coronary disease; Exclusion Criteria: * Hypo- or hyperthyroidism, * Rheumatic disease, * Use of alcohol, * hepatic failure, * renal failure * hormone replacement therapy * use of insulin
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What it tests

  • Trans-resveratrol, 1000 mg daily for 90 days
  • Placebo
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Where

1 site
Servico de Prevencao, Cardiopatia na Mulher e Reabilitacao Cardiovascular, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP,
São Paulo, Brazil
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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