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Advanced Space-time Resolved Techniques for Functional Neuroimaging at 7 Tesla MRI

RecruitingNAAges 6 Years - 65 YearsAllImago 7 Fondazione di Ricerca onlus
NCT07865546 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In recent years, the in vivo study of the central nervous system has undergone significant advancement through the implementation of magnetic resonance imaging (MRI)-based neuroimaging techniques. In particular, the advent of high- and ultra-high-field MRI systems has substantially contributed to a deeper understanding of the pathophysiological mechanisms underlying neurological diseases and has supported the development of personalized approaches in medicine. In the field of neuroimaging, the application of MRI techniques to investigate brain function and connectivity in vivo is increasingly expanding at ultra-high magnetic field strength (7T). This research project aims to develop, implement, and optimize advanced techniques to improve image quality through deep learning-based approaches and real-time monitoring of magnetic field fluctuations, with the goal of achieving functional neu

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📋 Eligibility rules (as published)
Inclusion criteria Healthy Volunteers * Age ≥ 18 years; * No history of diagnosed psychiatric disorders; * Sufficient understanding of the Italian language (required both for informed consent and for comprehension of fMRI task instructions); * Provision of written informed consent. Patients * Age 6-65 years; * Diagnosis of drug-resistant epilepsy (PMID: 19889013), with or without structural brain abnormalities, and candidate for surgical treatment (PMID: 21145290, 24497269, 31876960), or presence of pre-, peri-, or post-natal brain lesions documented by prior brain MRI; * Normal intellectual functioning or mild cognitive impairment sufficient to ensure adequate collaboration during the 7T functional neuroimaging study; * Sufficient understanding of the Italian language (required both for informed consent and comprehension of fMRI task instructions); * Provision of written informed consent (and assent when applicable, according to age and regulations). Exclusion Criteria (All Participants) * Contraindications to 7T MRI; * Neuropsychiatric comorbidities preventing adequate collaboration during functional neuroimaging; * Pregnancy; * Refusal to receive information regarding incidental findings identified during MRI examination.
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What it tests

  • Functional neuroimaging
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Where

1 site
Imago7 Foundation
Pisa, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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