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Randomised Controlled Trial Comparing CD62L and CD45RA Depleted Donor Lymphocyte Infusion With T-cell Depleted Haploidentical Hematopoietic Stem Cell Transplantation

RecruitingPhase 2Ages any - 18 YearsAllHong Kong Children's Hospital
NCT07867769 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of clinical trial is to compare the efficacy and safety of CD62L depleted donor lymphocyte infusion (DLI) with CD45RA depleted DLI in children who receive T-cell depleted haploidentical hematopoietic stem cell transplantation (HSCT). Participants will be randomised to receive either CD62L depleted DLI or CD45RA depleted DLI with HSCT and evaluate for efficacy and safety outcomes.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged 0-18 years who requires allogeneic hematopoietic stem cell transplant, has no HLA-matched sibling donor but has an HLA-haploidentical donor. * Adequate organ function to tolerate the conditioning chemotherapy and radiotherapy. * Karnofsky or Lansky performance status score ≥50 Exclusion Criteria: * Pregnant or lactating woman * HIV infection * Patients for whom alternative treatment is deemed more appropriate * Patients who are unlikely to benefit from haploidentical HSCT, e.g., terminal malignancy with multiorgan failure
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What it tests

  • CD62L depleted DLI
  • CD45RA depleted DLI
  • Haploidentical HSCT
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Where

1 site
Hong Kong Children's Hospital
Hong Kong, Hong Kong
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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