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Melatonin Effect on Immediate Dental Implants in the Posterior Mandible

RecruitingNAAges 20 Years - 50 YearsAllFuture University in Egypt
NCT07869030 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This pilot randomized controlled clinical trial aims to evaluate the feasibility, clinical safety, and preliminary radiographic osteogenic effects of applying topical 1% w/w melatonin gel during immediate implant placement in the posterior mandible. The study assesses surgical feasibility, soft-tissue healing, bone density, buccal bone thickness, and implant stability to provide preliminary effect size and variance estimates to inform future definitive clinical trials.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged 20-50 years. * Indicated for extraction and immediate implant placement in the posterior mandibular molar region. * Good oral hygiene and compliance with postoperative instructions. * Non-smokers or light smokers (≤10 cigarettes/day). * Patients who provide written informed consent and agree to attend follow-up visits. Exclusion Criteria: * Patients with systemic diseases affecting bone metabolism or wound healing (e.g., uncontrolled diabetes, osteoporosis). * Heavy smokers (\>10 cigarettes/day). * History of head and neck radiotherapy or chemotherapy. * Pregnant or lactating women. * Sites with acute infection, cystic lesions, or pathology. * Bruxism or parafunctional habits. * Use of medications affecting bone turnover (e.g., bisphosphonates, corticosteroids). * Poor compliance or unwillingness to return for follow-up visits.
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What it tests

  • 1% w/w Melatonin Gel
  • Standard Immediate Dental Implant Placement
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Where

1 site
Department of Oral and Maxillofacial Surgery, Faculty of Oral and Dental Medicine - Future University in Egypt
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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