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Acute Treatment of Vestibular Migraine by Rimegepant

RecruitingPhase 4Ages 18 Years - 60 YearsAllWensheng Qu
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In plain words

What the trial is, and whether it could suit you

To evaluate whether rimegepant improves acute vestibular symptoms and accompanying discomforts in patients with vestibular migraine.

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age 18-60 years, male or female. 2. Diagnosis of vestibular migraine according to the Bárány Society criteria. 3. ≥4 episodes of characteristic vestibular symptoms in the past year, each of moderate to severe intensity and lasting \>2 hours (without intervention). 4. Signed informed consent obtained from the participant. Exclusion Criteria: 1. Presence of other disorders causing acute vestibular symptoms (e.g., Ménière's disease, otitis media). 2. Coexisting non-vertiginous dizziness (e.g., dizziness due to panic disorder), unless the patient can clearly distinguish these episodes from vestibular-migraine attacks. 3. Severe hepatic dysfunction (ALT and/or AST \>3× upper limit of normal) or renal impairment (creatinine clearance \<30 mL/min). 4. Severe cardiovascular or cerebrovascular disease. 5. Alcohol abuse or substance abuse. 6. Known pregnancy or lactation, or a positive pregnancy test prior to randomization. 7. Contraindication or hypersensitivity to any medications used in the study. 8. Initiation or dose adjustment of any preventive migraine therapy within 3 months prior to study drug administration. 9. Use of any other anti-vertigo or analgesic medication within 6 hours before study drug administration. 10. Participation in another interventional clinical study that could affect outcome assessment. 11. Any other condition that, in the investigator's judgment, makes the participant unsuitable for the study or poses significant risk.
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What it tests

  • First dose rimegepant, second dose placebo
  • First dose placebo, second dose rimegepant
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Where

1 site
Tongji Hospital
Wuhan, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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