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Association Between Intraoperative Pulse Pressure Variation and Postoperative Lactate Clearance in Cardiac Surgery

Recruitingn/aAges 18 Years - 80 YearsAllElzem SEN
NCT07871188 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to evaluate the relationship between intraoperative pulse pressure variation (PPV) and postoperative lactate clearance in adult patients undergoing elective cardiac surgery. Intraoperative PPV values will be recorded, and blood lactate levels will be measured at admission to the intensive care unit and at 6 and 12 hours postoperatively. The study will investigate whether intraoperative PPV is associated with postoperative lactate clearance. This is a prospective observational study, and no additional interventions will be performed beyond routine clinical care.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults aged 18-80 years. * Patients undergoing elective coronary artery bypass graft (CABG) surgery. * Patients receiving invasive arterial blood pressure monitoring and mechanical -ventilation during surgery. * Patients planned for postoperative admission to the intensive care unit. * Patients whose informed consent has been obtained. Exclusion Criteria: * Patients with cardiac arrhythmias that may interfere with PPV measurement, such as atrial fibrillation. * Patients with severe aortic regurgitation. * Patients undergoing emergency cardiac surgery. * Patients receiving off-pump CABG. * Patients requiring spontaneous breathing or low tidal volume ventilation (\<6 mL/kg) during PPV measurement. * Patients with missing or insufficient intraoperative hemodynamic or postoperative lactate measurements.
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What it tests

  • No Study-Specific Intervention
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Where

1 site
Gaziantep University Hospital
Gaziantep, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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