💬In plain words
What the trial is, and whether it could suit you
Preeclampsia is a multisystemic and multifactorial disorder that complicates pregnancy and is characterized by new-onset hypertension after the 20th week of gestation accompanied by proteinuria or systemic findings such as renal dysfunction, hepatic dysfunction, pulmonary edema, thrombocytopenia, or neurological symptoms including headache and visual disturbances. It represents a significant risk factor for maternal and fetal morbidity and mortality.
In normal pregnancy, trophoblasts invade and dilate the maternal spiral arteries, thereby increasing uteroplacental blood flow. In preeclampsia, however, inadequate trophoblastic invasion leads to defective placentation, resulting in uteroplacental hypoperfusion and ischemia. The hypoxic and ischemic placenta releases anti-angiogenic mediators into the maternal circulation, which disrupt maternal endothelial function. This endothelial dysfu
Sign in to get the eligibility rules as simple questions to take to your doctor.
📋 Eligibility rules (as published)
Inclusion Criteria:
\-
Female participants aged 18-45 years.
Willingness to participate in the study and provision of written informed consent.
Absence of ocular media opacities that could interfere with Optical Coherence Tomography (OCT) or Optical Coherence Tomography Angiography (OCTA) imaging (e.g., dense cataract or vitreous hemorrhage).
No history of previous ocular surgery.
No high refractive error (refractive error greater than ±6 diopters).
Singleton pregnancy for participants in the pregnant groups.
Preeclampsia group:
Diagnosis of preeclampsia after the 20th week of gestation according to established clinical criteria.
No history of chronic hypertension, diabetes mellitus, chronic kidney disease, retinopathy or other ocular diseases, systemic vasculitis, or collagen vascular disease prior to pregnancy.
Healthy pregnant control group:
Healthy pregnancy without preeclampsia or hypertensive disorders of pregnancy.
No history of hypertension, diabetes mellitus, chronic kidney disease, retinopathy or other ocular diseases, systemic vasculitis, or collagen vascular disease.
Healthy non-pregnant control group:
Healthy non-pregnant women without a history of hypertension, diabetes mellitus, chronic kidney disease, retinopathy or other ocular diseases, systemic vasculitis, or collagen vascular disease.
Exclusion Criteria:
\- History of chronic hypertension prior to pregnancy.
Diagnosis of diabetes mellitus (DM) or gestational diabetes mellitus (GDM).
Presence of chronic kidney disease.
History of retinopathy or other ocular diseases, including glaucoma, uveitis, retinal detachment, or macular pathology.
Multiple pregnancy (twin pregnancy or higher-order gestation).
History of systemic vasculitis or collagen vascular disease.
History of previous ocular surgery.
Presence of high refractive error (greater than ±6 diopters).
Poor image quality preventing reliable analysis of Optical Coherence Tomography (OCT) or Optical Coherence Tomography Angiography (OCTA) images.
Failure to provide written informed consent.
Age below 18 years or above 45 years.
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