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Effect of Curcumin Topical Spray on Wound Healing After Tooth Extraction

RecruitingNAAges 18 Years - 40 YearsAllIstanbul University
NCT07874789 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This randomized, single-blind, controlled clinical trial aims to evaluate the effects of a topical curcumin spray on post-extraction wound healing and postoperative symptoms in adults undergoing first molar extraction. Participants will be randomly assigned to one of three groups: curcumin topical spray, 0.12% chlorhexidine topical spray, or standard postoperative care without a topical spray. The interventions will be applied twice daily for 7 days. Postoperative pain will be assessed using a visual analog scale, while wound healing will be evaluated using the Landry, Turnbull, and Howley Healing Index. Wound dimensions will also be recorded during follow-up. In addition, salivary levels of inflammatory biomarkers, including interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α), and prostaglandin E2 (PGE2), will be analyzed to assess the local inflammatory response during the post

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📋 Eligibility rules (as published)
Inclusion Criteria: * Healthy individuals aged 18-40 years with ASA physical status I. * Patients scheduled for extraction of a mandibular first molar. * Individuals who voluntarily agree to participate and provide written informed consent. * Individuals without chronic systemic disease and who do not use regular medication. * Patients with no oral health condition that would contraindicate the surgical procedure. Exclusion Criteria: * Pregnant or breastfeeding individuals. * Patients with systemic diseases or immunosuppression. * Individuals with a history of previous surgery or trauma in the same region. * Individuals with a known allergy or hypersensitivity to turmeric (curcumin), chlorhexidine spray, or any component of the study products. * Individuals who smoke or consume alcohol. * Individuals who regularly use medications, particularly anti-inflammatory or anticoagulant drugs.
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What it tests

  • Curcumin Topical Spray
  • Chlorhexidine Topical Spray
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Where

1 site
Istanbul University Faculty of Dentistry, Department of Oral and Maxillofacial Surgery
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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