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Association of Inspiratory Effort With Dyspnea During Assisted Mechanical Ventilation in Critically Ill Patients

Recruitingn/aAges 18 Years - anyAllUniversity of Crete
NCT07877350 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

During assisted mechanical ventilation, breathing results from the interaction between the patient and the ventilator. Optimal titration of pressure support is essential to maintain a balance between over-assistance and under-assistance. Excessive respiratory may lead to dyspnea and cause respiratory muscle fatigue, whereas excessive assistance promotes muscle atrophy and delays weaning. Although normal inspiratory effort values in healthy subjects are well defined, acceptable limits in critically ill patients remain unclear. Inspiratory effort is traditionally quantified by the pressure-time product (PTP), but its measurement is technically demanding. Simpler indices such as swings of esophageal pressure (ฮดPes) and airway occlusion pressure at 100 ms (P0.1) are used more often, both with important limitations. Dyspnea, a frequent and distressing symptom among mechanically ventilated cri

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Adult patient admitted to the ICU. * Receiving invasive assisted mechanical ventilation in a pressure-support mode or another assisted mode permitting measurement of the prespecified variables. * Prolonged or difficult weaning. * Receiving pressure support of at least 5 cmH2O at screening. * Written informed consent from the participant or legally authorized representative, in accordance with local ethics requirements. * Ability to undergo the planned physiological monitoring and dyspnea assessment. Exclusion Criteria: * Contraindication to nasogastric placement or to placement/use of an esophageal-gastric balloon catheter for Pes and Pgas measurement. * Refusal of consent by the participant or legally authorized representative. * Any clinical condition in which the treating physician considers study measurements or pressure-support titration unsafe (unstable hemodynamics, uncontrolled arrhythmia, severe hypoxemia, active myocardial ischemia etc.)
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What it tests

  • Not listed
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Where

1 site
University Hospital of Heraklion
Heraklion, Greece
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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