Impact of Cognitive Impairment on Chronic Pain in Breast Cancer

Inclusion criteria: * Female patients aged 35 to 65 years * Signed informed consent * Affiliated with the French social security system or entitled beneficiary * Able to read and understand French * Willing to participate and able to comply with study procedures * Diagnosed with non-metastatic, hormone receptor-positive breast cancer * No prior chemotherapy exposure * Adjuvant treatment setting after surgery) * Receiving the same treatment sequence: surgery, chemotherapy (anthracycline- and taxane-based regimens), radiotherapy, and hormone therapy. Exclusion criteria: * Central nervous system disorders * MMSE score \<26 assessed by the psychologist at the beginning of the inclusion visit (post-inclusion exclusion criterion if MMSE \<26) * Use of tricyclic antidepressants at doses ≥75 mg/day; benzodiazepines or antipsychotics * Morbid obesity * Psychiatric disorders (psychosis, major depressive episode, according to DSM-5 diagnostic criteria as assessed by the MINI, or history of suicide attempt) * Alcohol, drug, or psychoactive substance abuse (DSM-5 definition) within the past six months * Persistent or intermittent chronic pain conditions (e.g., irritable bowel syndrome) prior to inclusion * Cognitive or psychological disorders incompatible with protocol adherence and/or comprehension * Ongoing legal dispute or compensation-seeking process * Protected persons as defined in Articles L.1121-5 to L.1121-8 of the French Public Health Code: pregnant or breastfeeding women, prisoners or individuals under judicial or administrative detention, individuals receiving psychiatric care, minors, or adults under legal protection or unable to provide informed consent