Comparative Study of Combination Treatment of Bionerv E+ Versus Vitamin B Complex in Treatment of Diabetic Polyneuropathy in Type 2 Diabetic Patients and Its Effect on Wound Healing

Inclusion Criteria: 1. Aged 18 years and above 2. Diagnosed with Type 2 Diabetes Mellitus 3. HbA1C of \<8% 4. Symptoms of DSPN attributed by diabetes mellitus using Toronto Clinical Neuropathy Scoring (TCNS) 5. No recent changes of medications for DSPN for the last 3 months 6. Neuropathy Impairment Score (NIS) for lower limbs ≥ 2 points 7. DFU is classified as Wagner 1 or 2 on the Wagner classification system. 8. Patients with type 1 or type 2 diabetes with a non-healing foot ulcer of at least 4 weeks' duration. 9. If more than one non-healing wound is present, the largest wounds that are classified as a Wagner 1 or 2 will be selected. 10. The index ulcer has to be clinically non-infected. 11. Ankle Brachial Index (ABI) higher than or equal to 0.7. 12. Index foot ulcers that are located on the plantar, medial, or lateral aspect of the foot (including all toe surfaces). 13. Wound area (length X width) measurement between 2 cm2 and 20 cm2. 14. Non-use of drugs that may interfere with wound healing, such as corticosteroids, immunosuppressive, and cytotoxic agents. 15. No smoking, alcohol or drug addiction. 16. Approved, informed, signed consent. Exclusion Criteria: * 1\. Previous consumption of vitamin E and other antioxidants, taking anti-inflammatory agents for the past 3 months. 2\. Presence of other neurological disorders causing neuropathy / myopathy 3. Presence of peripheral vascular disease with ABSI \<0.8 4. Use of anti-oxidants or Pentoxyphylline within the last 3 months 5. Use of ALA or ALA-containing substance within the last 3 months 6. End stage renal disease 7. Liver impairment 8. Psychiatry illness 9. Cancer patients 10. History of lower limb amputations (Ray amputation not excluded) 11. Index ulcer has exposed tendons, ligaments, muscle, or bone. 12. Confirmed presence of osteomyelitis, or if osteomyelitis is suspected.