Pilot Study: Evaluation of the Safety of the Application of Non-thermal HIFU for Varicose Veins Treatment of the Lower Limbs

Inclusion Criteria: * Patient with C2-C3 superficial venous insufficiency (CEAP classification) and a refluxing saphenous vein verified by DUS (reflux \> 0.5 sec) * Great saphenous vein or anterior accessory saphenous vein reflux * Diameter of the saphenous vein lumen ≤ 6 mm * Depth of the vein in relation to the skin surface between 5 mm and 30 mm * Physical condition allowing an outpatient procedure * Patient aged 35 or higher * Willing and able to comply with all study requirements * Signature of informed consent Exclusion Criteria: * Venous lumen diameter \> 6mm * Saphenous Vein depth \> 30 mm or \< 5 mm * Skin alteration in the path of the vein to be treated * Target vein not clearly visible with DUS * Venous malformation * Present or history of deep vein or superficial vein thrombosis * Patients undergoing treatment with anticoagulants or antiplatelet agents * Patients undergoing analgesic therapy * Suffering from a severe comorbid condition (e.g., cancer, progressive hepatitis, heart failure, renal failure, lower limb artery disease, acute infection etc.) * Thrombophilia * Known patent foramen oval * Pregnancy, breastfeeding * Patients taking part in another interventional clinical trial involving an investigation of medicinal products, a medical device or a biological product * Patients under 35 years or over 80 years