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Shenfu Injection for the Prevention and Treatment of Ventilator Dependence in Mechanically Ventilated Patients

RecruitingNAAges 19 Years - 75 YearsAllThe Fourth Affiliated Hospital of Zhejiang Univer…
NCT07880977 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This multicenter randomized controlled trial aims to evaluate the efficacy of Shenfu Injection in preventing and treating ventilator dependence and ventilator-induced diaphragm dysfunction (VIDD) in critically ill adult patients receiving invasive mechanical ventilation. Eligible participants will be randomly assigned to receive Shenfu Injection or control treatment in addition to standard clinical care. Diaphragm function will be monitored using daily bedside ultrasonography, including diaphragm excursion and diaphragm thickness. Clinical outcomes will include successful ventilator weaning, time to successful weaning, and the need for resumption of mechanical ventilation within 48 hours after initial weaning. The study is intended to determine whether Shenfu Injection can improve diaphragm function and facilitate liberation from mechanical ventilation.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Critically ill patients requiring mechanical ventilation. * Age \>18 years and \<75 years. * No history of hypertension or diabetes mellitus. * No history of allergy to traditional Chinese medicine injections. Exclusion Criteria: * Motor neuron disease. * Guillain-Barré syndrome. * Myasthenia gravis. * Mitochondrial myopathy. * Severe thoracic deformity. * High cervical spinal cord injury or myelitis.
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What it tests

  • Shenfu Injection
  • 5% glucose injection
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Where

1 site
The Fourth Affiliated Hospital, Zhejiang University School of Medicine
Yiwu, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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