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Comparison of Topical Clascoterone 1% Cream Versus Adapalene 0.1% Cream in the Treatment of Mild-to-Moderate Acne Vulgaris

RecruitingNAAges 12 Years - 55 YearsAllPak Emirates Military Hospital
NCT07883538 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study will compare the effectiveness and safety of topical clascoterone 1% cream and adapalene 0.1% cream in patients with mild-to-moderate acne vulgaris. Acne is a common skin condition that causes blackheads, whiteheads, pimples, and inflammation. A total of 130 eligible participants aged 12-40 years will be enrolled in a randomized controlled trial at the Dermatology Outpatient Department of Pak Emirates Military Hospital, Rawalpindi, Pakistan. Participants will be randomly assigned to one of two treatment groups. Group A will receive clascoterone 1% cream applied twice daily, while Group B will receive adapalene 0.1% cream applied once daily at night. Treatment will continue for 12 weeks. Participants will be assessed at baseline and during follow-up visits at Weeks 4, 8, and 12. Treatment response will be evaluated using the Investigator's Global Assessment (IGA) score and ac

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Patients with clinically diagnosed mild-to-moderate acne vulgaris. 2. Patients willing to use the assigned treatment and attend scheduled follow-up visits. 3. Any gender between the ages of 12 and 55. Exclusion Criteria: 1. Acne-like eruptions caused by drugs or another identifiable condition. 2. Recent topical or systemic anti-acne treatment that may affect assessment of the study treatment. 3. Pregnancy or breastfeeding as both these treatments are contraindicated. 4. Known allergy or hypersensitivity to clascoterone, adapalene or their formulation components.
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What it tests

  • Clascoterone 1% cream
  • Adapalene 0.1% cream
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Where

1 site
Pak Emirates Military Hospital
Rawalpindi, Pakistan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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