Comparison of Two Pulse Field Ablation Systems for AF Ablation

Inclusion Criteria: * Symptomatic AF * Persistent AF * De novo AF ablation * Males and Females Age 18 to 89 years of age, inclusive * Willing and capable to provide informed consent * Able and willing to participate in all examinations and follow-up visits and tests associated with this clinical study Exclusion Criteria: * AF secondary to electrolyte imbalance, thyroid disease, alcohol abuse, or other reversible/non-cardiac causes * Contraindication to, or unwillingness to use, systematic anticoagulation * Left ventricular ejection fraction LVEF 30% as documented by TTE (within 3 months prior) * Left atrial volume index \>60 ml/m2 * LA anteroposterior dimension 5.5 cm * Presence of intramural thrombus, tumor or other abnormality that precludes safe catheter introduction or manipulation * BMI \>35 kg/m2 * Chronic renal insufficiency of \<15 mL/min/1.73 m2 or any history of renal dialysis, or history of renal transplant * Clinically significant systemic infection or sepsis * Any of the following within the 3-months prior to enrollment: * Myocardial infarction * Unstable angina * Percutaneous coronary intervention * Heart failure hospitalization * Stroke or TIA * Significant bleeding * Pericarditis/effusions * Left atrial thrombus * Coronary artery bypass grafting/atriotomy within 6 months prior * Contraindication for oral anticoagulation * Organ or hematologic transplant, or currently being evaluated for an organ transplant Women who are pregnant or breastfeeding