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Dexmedetomidine for Refractory Pain in Palliative Cancer Patients

Recruitingn/aAges 18 Years - anyAllSt. Olavs Hospital
NCT07885475 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this study is to find out whether the medication dexmedetomidine can be a safe and effective additional treatment for cancer patients whose pain is not well controlled by standard pain medicines (such as opioids). The study includes 30 palliative care patients who still have significant pain despite standard pain treatment. All participants will receive dexmedetomidine, and outcomes related to efficacy and safety will be systematically observed.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult cancer patients (\>18 years), not receiving curative treatment * Treated with parenteral opioids for cancer-related pain * Indication to start dexmedetomidine treatment due to uncontrolled background pain (NRS \> 4 in a numeric rating scale (NRS 0-10)) despite hospitalization and standard pain management. Exclusion Criteria: * Dexmedetomidine hypersensitivity * Hypotension (systolic blood pressure (BP) \< 90) * Bradycardia (heart rate (HR) \< 50) * Serious heart disease or AV block grade 2 or 3 if no pacemaker. * Severe liver failure (e.g. Child-Pugh-C or similar) * Acute cerebrovascular disease * Neuraxial pain management * Patients unable to comply with trial procedures
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What it tests

  • Not listed
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Where

4 sites
Drammen Hospital
Drammen, Norway
Oslo University Hospital
Oslo, Norway
Univsersity Hospital of North Norway
Tromsø, Norway
St.Olavs Hospital, Trondheim Univsersity Hospital
Trondheim, Norway
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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