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Extracorporeal Shock Wave Therapy in the Treatment of Periarticular Bone Marrow Edema in Patients With Knee Osteoarthritis

RecruitingNAAges 40 Years - 70 YearsAllDokuz Eylul University
NCT07887893 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Bone marrow edema (BME) is a radiological finding characterized by increased fluid content and structural changes within the bone marrow. It most commonly affects weight-bearing joints such as the hip, knee, and ankle. Patients with BME may present with pain during activity or at rest, tenderness, swelling, joint effusion, and limitation of joint motion. Magnetic resonance imaging (MRI) is considered the gold standard for diagnosis. BME is commonly observed in patients with knee osteoarthritis (OA) and may be associated with increased pain, impaired joint function, and progression of structural joint damage. Therefore, recognition and treatment of BME may be clinically important in patients with knee OA. Treatment options for BME include conservative and surgical approaches. Standard conservative treatment generally includes activity and weight-bearing modification, analgesics and nons

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged 40-70 years * Radiographic evidence of knee osteoarthritis classified as Kellgren-Lawrence grade 2 or 3 * Unilateral BME in the bones around the knee, limited to either the medial or lateral compartment of the knee joint, as confirmed by MRI. The affected sites may include the medial femoral condyle, medial tibial plateau, or both; or the lateral femoral condyle, lateral tibial plateau, or both * Willingness to participate in the study * Provision of written informed consent Exclusion Criteria: * Insufficient cognitive ability to complete the questionnaires * Physical therapy, corticosteroid injection, or surgery involving the affected area within the previous 6 months * Previous ESWT treatment * Open wounds, infection, bleeding, skin lesions, or metal implants around the knee * Presence of a cardiac pacemaker * Peripheral arterial occlusive disease * Polyneuropathy or sensory impairment * Inflammatory rheumatic disease * Severe cardiovascular disease * Pregnancy * History of epilepsy * History of malignancy * Bleeding disorders
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What it tests

  • Radial Extracorporeal Shock Wave Therapy
  • Sham Radial Extracorporeal Shock Wave Therapy
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Where

1 site
Dokuz Eylul University
Izmir, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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