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Study of the Link Between Structural Alterations in the Hypothalamus and Cardiac Dysautonomia in Drug-resistant Epilepsy

RecruitingNAAges 18 Years - anyAllCentre Hospitalier Universitaire, Amiens
NCT07888543 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Patients with drug-resistant epilepsy may have cardiac dysautonomia, with reduced heart rate variability and increased sympathetic tone. This condition is part of the concept of "epileptic heart" and could be a risk factor for sudden death, one of the main causes of excess mortality in patients with severe epilepsy in adulthood. The mechanism of this cardiac impairment is poorly understood. The hypothalamus, due to its role as the subcortical conductor of the autonomic nervous system and its known links with the limbic system, particularly the amygdala and hippocampus, is a candidate for a key intermediary role in the impact of seizures on cardiorespiratory function. The investigators wish to investigate the hypothesis that cardiac dysautonomia in patients with drug-resistant epilepsy is correlated with structural changes in the hypothalamus. The investigators wish to study in 7Tesla MRI

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients \> 18 years old * With drug-resistant epilepsy * Followed up at Amiens Picardie University Hospital * With at least one seizure recorded by video-EEG (or SEEG) in the 4 years prior to inclusion * Having had a good-quality electroencephalogram with ECG within the last 6 months prior to inclusion * Having given their informed consent, both verbally and in writing. * Covered by Social Security Exclusion Criteria: * Pregnant women * Contraindications to MRI * Claustrophobia, or any other condition that prevents the patient from remaining in the MRI machine for 40 minutes * History of cardiovascular disorders: arrhythmia, conduction disorders, myocardial infarction, high blood pressure. * History of endocrine disorders, precocious puberty, intellectual disability, eating disorders (obesity BMI\>35, anorexia) * Patients with dissociative functional seizures * Patients with epilepsy related to hypothalamic hamartoma or a genetic cause identified in genes coding for ion channels, particularly SCN1A, SCN1B, and CACNa1a
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What it tests

  • MRI scan
  • electrocardiogram
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Where

1 site
Amiens University Hospital
Amiens, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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