🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Effect of Resistance Exercises on Serum IGF-1 Levels in Knee Osteoarthritis

RecruitingNAAges 40 Years - 75 YearsAllSisli Hamidiye Etfal Training and Research Hospit…
NCT07890155 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to evaluate the effects of a resistance exercise program on serum Insulin-like Growth Factor 1 (IGF-1) levels in patients with knee osteoarthritis. Specifically, it aims to investigate the relationship between changes in serum IGF-1 levels and clinical improvement after exercise therapy, and to evaluate the impact of the presence of osteoarthritis metabolic phenotype on this relationship. Participants will be asked to complete a structured resistance exercise program for 8 weeks. Researchers will compare the pre-exercise and post-exercise serum IGF-1 levels, clinical scores (WOMAC, VAS) and radiological findings (MOAKS Osteophyte Score) to determine the effectiveness of the intervention.

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Diagnosis of knee osteoarthritis according to the American College of Rheumatology (ACR) clinical and radiographic criteria. * Radiological severity of Kellgren-Lawrence (KL) grade 2 or 3 on standing anteroposterior knee radiographs * Having a knee magnetic resonance imaging (MRI) scan obtained within the past 1 year * Age between 40 and 75 years * Volunteering to participate in the study and signing the informed consent form Exclusion Criteria: * Receiving intra-articular injections (e.g., corticosteroids, hyaluronic acid, PRP) in the affected knee within the last 6 months * History of previous major knee surgery, knee arthroplasty, or lower extremity trauma affecting biomechanics * Diagnosis of rheumatoid arthritis, or other inflammatory joint diseases * Presence of severe cardiovascular, neurological, or musculoskeletal disorders that would contraindicate or prevent participation in a structured resistance exercise program * History of malignancy or presence of active malignancy * Presence of active infection * Cognitive impairment or inability to understand and follow the exercise instructions and questionnaires
💊

What it tests

  • Resistance Exercise Program
📍

Where

1 site
Sisli Hamidiye Etfal Training and Research Hospital
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy