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Physiology-directed Epinephrine Dosing in Pediatric Cardiac Arrest

Recruitingn/aAges 37 Weeks - 18 YearsAllChildren's Hospital of Philadelphia
NCT07890610 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of this study is to evaluate the physiologic response to epinephrine as an outcome discriminator in pediatric in-hospital cardiac arrest (IHCA). In addition, the investigators will determine optimal epinephrine dosing strategies based on the initial physiologic response to epinephrine, and to develop machine learning (ML) algorithms to guide intra-arrest therapy.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Arrest in an ICU * Patients received chest compressions for at least 1 minute Exclusion Criteria: * Lack of commitment to aggressive therapies (e.g., CPR performed as part of end-of-life care) * Brain death determination prior to CPR * Out-of-hospital cardiac arrest was the reason for initial admission to the hospital (known poor outcomes) * Supported by Veno-Arterial Extra Corporeal Membrane Oxygenation at the start of CPR
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What it tests

  • Not listed
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Where

22 sites
CHOC
Orange, United States
Stanford Medicine Children's Health
Stanford, United States
Children's Hospital Colorado
Denver, United States
Nemours Children's Health
Wilmington, United States
Children's Healthcare of Atlanta
Atlanta, United States
Comer Children's Hospital
Chicago, United States
Riley Children's Health
Indianapolis, United States
Stead Family Children's Hospital
Iowa City, United States

…and 14 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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