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Understanding the Subnormal Rescue ofNeurological Development in Congenital Hypothyroidism (2022E5SZEM)

Recruitingn/aAges 28 Days - anyAllIstituto Giannina Gaslini
NCT07893522 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Congenital hypothyroidism (CH) is a condition present at birth in which the thyroid gland does not produce enough thyroid hormones. These hormones are essential for normal brain development. Although early diagnosis through newborn screening and treatment with thyroid hormone help prevent serious learning difficulties, some children with CH may still experience difficulties with thinking, learning, or development. This study aims to understand why some children with CH do not achieve the expected level of neurological and cognitive development despite early treatment. The researchers will study 39 patients with CH and compare them with 39 similar individuals without the condition. They will also study 50 children with mild neonatal hyperthyrotropinemia (MNH), a condition involving mildly elevated thyroid-stimulating hormone levels, and compare them with 50 children without the condition

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults and minors with congenital hypothyroidism (CH). * Family members of patients with CH. * Healthy controls without thyroid-related conditions or other conditions that could interfere with the study. Exclusion Criteria: * Refusal to provide informed consent to participate in the study. * Intercurrent conditions or severe comorbidities that could interfere with study procedures.
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What it tests

  • Not listed
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Where

3 sites
IRCCS Istituto G. Gaslini
Genova, Italy
Istituto Auxologico Milano
Milan, Italy
UOS di Endocrinologia Pediatrica del Dipartimento Assistenziale ad Attivita' Integrata Materno nfantile dell'Azienda Ospedaliera Universitaria Federico II di Napoli
Naples, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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