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Renal Denervation in Patients With Atrial Fibrillation and Hypertension

RecruitingNAAges 18 Years - anyAllPavel Antiperovitch
NCT07893821 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

High blood pressure is a major risk factor for atrial fibrillation (AF), an irregular heart rhythm, and heart failure with preserved ejection fraction (HFpEF), a condition in which the heart becomes stiff and cannot relax properly. Both conditions can significantly affect quality of life and frequently occur together. In individuals with high blood pressure, increased activity of the nerves surrounding the kidneys can further elevate blood pressure and contribute to strain on the heart. Renal denervation (RDN) is a procedure designed to lower blood pressure by reducing the activity of these nerves using a thin catheter and controlled energy. RDN has been shown to lower blood pressure safely in many patients; however, the potential benefits in individuals with concurrent AF and HFpEF remain uncertain. This pilot study will be conducted in two phases. Phase 1 will assess the safety and f

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age ≥18 years 2. Scheduled for EP study +/- catheter ablation 3. Adequate renal function (eGFR ≥45 mL/min/1.73m²) Exclusion Criteria: 1. Hemodynamic instability 2. Renal artery stenosis \>50% 3. Single functioning kidney 4. Previous renal artery intervention 5. Pregnancy or nursing 6. Life expectancy \<12 months 7. Unwilling or unable to provide informed consent 8. Participation in a clinical trial that may impact the outcomes of the current study
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What it tests

  • Catheter-based renal artery electrical stimulation (as a feasibility assessment for renal denervation)
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Where

1 site
London Heart Rhythm Program
London, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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