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Toxicity of Intensive First-Line Treatment for Adult Burkitt Lymphoma: A Retrospective Observational Study

Recruitingn/aAges 18 Years - anyAllUniversity Hospital, Strasbourg, France
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In plain words

What the trial is, and whether it could suit you

Burkitt lymphoma is a rare, highly aggressive B-cell non-Hodgkin lymphoma in adults. Although intensive multi-agent chemotherapy can achieve high complete remission rates, it is associated with substantial toxicity, morbidity, and sometimes treatment-related mortality. This retrospective, single-center observational study aims to characterize the short- and long-term complications of intensive first-line treatment in adults with Burkitt lymphoma managed at Strasbourg University Hospitals. The study will evaluate treatment-related toxicities, overall survival at five years, and progression-free survival at 24 months. Secondary objectives include assessing treatment delays, chemotherapy dose reductions, and their associations with toxicity, disease location at diagnosis, and survival. All eligible adult patients diagnosed with Burkitt lymphoma or managed for this condition at Strasbourg

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults aged 18 years or older. * Patients diagnosed with Burkitt lymphoma at Strasbourg University Hospitals between January 1, 2009, and December 31, 2025, and/or managed by the Hematology Department of Strasbourg University Hospitals or ICANS for Burkitt lymphoma during this period. * No written objection documented in the medical record to the reuse of personal data for scientific research. Exclusion Criteria: * Patients who have objected to the reuse of their personal data for scientific research. * Patients diagnosed with another B-cell non-Hodgkin lymphoma other than Burkitt lymphoma. * Patients for whom accessible data are unavailable. * Individuals under legal protection (sauvegarde de justice). * Individuals under guardianship or curatorship (tutelle or curatelle).
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What it tests

  • Not listed
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Where

1 site
Service d'Hématologie et d'Oncologie - CHU de Strasbourg, France
Strasbourg, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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