A Phase I Study of Intra-Arterial Yttrium-90 Radioembolization for Unresectable Pancreatic Cancer

Inclusion Criteria: * Histologically confirmed pancreatic adenocarcinoma (T4N0/1M0/1) * ECOG performance status 0-1, for at least 2 weeks * Life expectancy ≥12 weeks * Signed informed consent for participation Exclusion Criteria: * ECOG \>2 or Karnofsky score \<60% * Active gastrointestinal ulcers or recent GI bleeding (\<3 months) * Active Hepatitis B/C or other significant infectious disease * Uncontrolled cardiovascular disease (NYHA class III/IV heart failure, recent MI, severe arrhythmias) * Significant haematological abnormalities (ANC \<1.5×10⁹/L, platelets \<100×10⁹/L, haemoglobin \<8 g/dL) * Severe hepatic dysfunction (total bilirubin \>1.5×ULN, ALT/AST \>4×ULN without liver metastases) * Prior solid organ transplant * Pregnancy or lactation * Any condition deemed by investigators as unsafe for participation