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Impact of Delivery Mode on Infant Gut Microbiota, Visceral Sensitivity, and the Neuroenteric System

Recruitingn/aAges 2 Days - 4 DaysAllInstitut National de Recherche pour l'Agriculture…
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In plain words

What the trial is, and whether it could suit you

The bacteria and other microorganisms that naturally live in the gut (the gut microbiome) play an important role in a baby's early development. Babies born by cesarean section are exposed to different microorganisms at birth than babies born vaginally, which may affect the normal establishment of the gut microbiome.Early changes in the gut microbiome can affect the development and function of the immune system, as well as metabolism and gut function, and may increase the risk of certain diseases later in life. They have also been associated with infant colic, a common condition that may be related to increased sensitivity to abdominal pain. Current approaches to restore the gut microbiome after cesarean birth, such as transferring the mother's vaginal or fecal microbiota, raise important safety concerns. This study aims to better understand how differences in the early gut microbiome in

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📋 Eligibility rules (as published)
Inclusion Criteria of the babies : * 2 to 4 days old * Born vaginally or by cesarean section * Gestational age at birth ≥ 37 weeks of amenorrhea * Exclusively breastfed * With no known medical conditions * Not receiving any medical supplements other than standard vitamins * Whose mothers did not take antibiotics during the third trimester of pregnancy, other than those administered at the time of the cesarean section * Whose mothers did not take probiotics during the third trimester of pregnancy * Whose mothers did not have gestational diabetes * Whose mothers do not have any known chronic medical conditions * Whose mothers did not undergo any chronic treatment * Whose mothers had a body mass index (BMI) below 25 at the start of pregnancy * Whose mothers provided consent to participate in the study and to have their babies' stool samples collected * Whose mothers are not deprived of their liberty or under legal guardianship Exclusion Criteria of the babies : * Older than 4 days * Born before 37 weeks of gestation * Not exclusively breastfed * Receiving medical supplementation other than conventional vitamins * With any type of medical condition * Whose mothers are under 18 years of age * Whose mothers received antibiotic therapy during the third trimester of pregnancy * Whose mothers took probiotics during the third trimester of pregnancy * Whose mothers have a chronic illness * Whose mothers are undergoing chronic treatment * Whose mothers developed gestational diabetes * Whose mothers had a BMI greater than 25 at the start of pregnancy * Whose mothers did not give consent to participate in the collection of their baby's stool samples * Whose mothers are deprived of their liberty or under legal guardianship
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What it tests

  • Not listed
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Where

1 site
Hopital Paris-Saclay (GHNE)
Orsay, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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