AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Standardized 4D Transperineal Ultrasound Assessment of Urethrovesical Junction Mobility After Vaginal Laser Treatment for Stress Urinary Incontinence.

Recruitingn/aAges 18 Years - anyFemaleCharles University, Czech Republic
💬

In plain words

What the trial is, and whether it could suit you

This prospective single-center observational cohort study will assess changes in urethrovesical junction (UVJ) mobility and urethral morphology after vaginal Er:YAG laser treatment in 40 adult women with pure stress urinary incontinence (SUI) or stress-predominant mixed urinary incontinence. Participants will independently choose self-paid laser treatment as routine clinical care before being offered study participation. Treatment comprises three sessions at 4-6-week intervals. Standardized 4D transperineal ultrasound and clinical assessments will be performed at baseline and 1, 3, and 6 months after the final session. The primary outcome is change in craniocaudal UVJ mobility, measured in millimeters, from baseline to 1 month after the final session. Secondary outcomes include UVJ mobility at 3 and 6 months, UVJ position, mid-urethral morphology, patient-reported outcomes, cough stres

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Female sex. * Age 18 years or older. * Pure stress urinary incontinence or stress-predominant mixed urinary incontinence. In women with mixed urinary incontinence, the stress component must be the dominant and most bothersome symptom. * Urodynamically demonstrated stress urinary incontinence. * Absence of detrusor overactivity on urodynamic testing. * Independent decision to undergo self-paid vaginal laser treatment as routine clinical care, made before the offer of study participation. * Ability to complete the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF). * Ability to perform a technically acceptable Valsalva maneuver. * Willingness to attend the scheduled follow-up visits. * Written informed consent to study participation. Exclusion Criteria: * Predominant overactive bladder or predominant urgency urinary incontinence. * Previous surgery for stress urinary incontinence. * Previous vaginal laser treatment. * Previous pelvic organ prolapse surgery. * Pelvic Organ Prolapse Quantification (POP-Q) stage II or greater in any compartment. * Current pessary use at enrollment. * Active pelvic floor physiotherapy at enrollment. * Previous pelvic radiotherapy. * Pregnancy. * Unexplained genital bleeding. * Pelvic malignancy. * Any other contraindication to vaginal laser treatment. * Active urinary tract or vaginal infection. Enrollment and laser treatment will be deferred until the infection has resolved.
💊

What it tests

  • Not listed
📍

Where

1 site
General University Hospital in Prague
Prague, Czechia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy