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Alzheimer's disease biomarker measurement

Alzheimer's disease biomarkers are used as indicators for Alzheimer's disease screening and as predictors for therapeutic responses and prognoses in Alzheimer patients

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๐Ÿงฌ1677genes / proteins with evidence
๐Ÿ’Š0drugs and clinical candidates
๐Ÿงช0recruiting trials worldwide
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Understand Alzheimer's disease biomarker measurement

Brain and nerves ยท Nerve cells that slowly stop working
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What it is

Alzheimer's disease biomarkers are used as indicators for Alzheimer's disease screening and as predictors for therapeutic responses and prognoses in Alzheimer patients

From the Open Targets disease record โ†—

๐Ÿง  Brain and nerves: In neurodegenerative diseases, nerve cells in the brain or spinal cord stop working and die over time - affecting memory (Alzheimer's disease), movement (Parkinson's disease) or muscles (ALS).

โ“ Why it happens

  • Proteins fold the wrong way and clump together inside or between nerve cells - amyloid and tau in Alzheimer's disease, alpha-synuclein in Parkinson's disease.
  • Inflammation, some genes (such as APOE4) and, above all, age raise the risk.

๐Ÿซ€ What it does to the body

  • As connections between nerve cells are lost, memory, thinking, movement or speech fade.
  • The changes start years - often decades - before the first symptoms.

๐Ÿงฑ Why it is hard to cure

  • Most medicines cannot easily pass the blood-brain barrier that protects the brain.
  • By the time symptoms appear, many nerve cells are already lost, and they do not grow back.
  • Many drug trials have failed, partly because the diseases are found late.

๐Ÿš€ What research is trying now

  • Antibodies that clear amyloid and modestly slow early Alzheimer's disease (approved in some countries).
  • Blood tests that detect Alzheimer's changes years earlier.
  • Gene-targeted medicines, such as one approved in the US for an inherited form of ALS.

General information about brain and nerves, reviewed by people; it does not describe any one person. Below: the evidence for Alzheimer's disease biomarker measurement itself.

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AI briefing

Where the science on Alzheimer's disease biomarker measurement stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands โ€” every claim cited. It is shared with everyone who opens Alzheimer's disease biomarker measurement.

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Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
APOE apolipoprotein EPROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.59
APOC1 apolipoprotein C1PROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.55
CR1 complement C3b/C4b receptor 1 (Knops blood group)PROTACantibodyother๐ŸงŠ AlphaFold structure โ†— 0.54
ABCA7 ATP binding cassette subfamily A member 7PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.53
CLU clusterinPROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.52
MS4A6A membrane spanning 4-domains A6Aantibody๐ŸงŠ AlphaFold structure โ†— 0.51
TREM2 triggering receptor expressed on myeloid cells 2antibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.50
BIN1 bridging integrator 1PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.50
PVR PVR cell adhesion moleculePROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.50
PLCG2 phospholipase C gamma 2PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.49
SORL1 sortilin related receptor 1PROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.49
NCK2 NCK adaptor protein 2PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.48
ACE angiotensin I converting enzymePROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.47
PTK2B protein tyrosine kinase 2 betaPROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.47
TNFRSF13B TNF receptor superfamily member 13BPROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.46

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

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Drugs and candidates

Every medicine linked to Alzheimer's disease biomarker measurement, by how far it has got

No drugs recorded yet.

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Recruiting trials

Worldwide, open to new patients now

No recruiting trials found.

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Newest research

Latest papers on PubMed
Tau extent is associated with lower cognition in Down syndrome-related Alzheimer's disease.Alzheimers Dement 2026 ยท PMID 42928420Noninvasive diagnosis of Alzheimer's disease: a review of emerging biomarkers and multimodal approaches.Front Cell Dev Biol 2026 ยท PMID 42923225Tandem Tau and ฮฑ-Synuclein Seed Amplification Assays Reveal ฮฑ-Synuclein Copathology Potentiates Tau Seeding in Alzheimer's Diseasโ€ฆRes Sq 2026 ยท PMID 42922684Evaluation of harmonization methods to mitigate assay and cohort effects in plasma p-tau217.Alzheimers Dement (Amst) 2026 ยท PMID 42921107Tau isoform mapping across tissues and biofluids reveals a signature distinguishing Alzheimer's disease from amyotrophic lateral โ€ฆNat Commun 2026 ยท PMID 42918778Osteoporosis and Alzheimer's Disease: The Role of Sclerostin.Curr Osteoporos Rep 2026 ยท PMID 42905237Systemic oxidative stress in patients with Alzheimer's disease.Free Radic Biol Med 2026 ยท PMID 42901282More than just accuracy: A pathway-level framework for implementing blood and digital biomarkers for Alzheimer's disease care.Neuron 2026 ยท PMID 42901167 Ask a research question in the Hypothesis Lab โ†’
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