AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

📰 Latest breakthroughs
🗺️ Disease Atlas · Nervous system disorder

Alzheimer's disease neuropathologic change

degenerative change that occurs in individuals with Alzheimer's disease, such as amyloid plaques, cerebral amyloid angiopathy, neurofibrillary tangles, neuronal loss or synaptic loss

🔔 Follow weekly
🧬8genes / proteins with evidence
💊0drugs and clinical candidates
🧪0recruiting trials worldwide
🧠

Understand Alzheimer's disease neuropathologic change

Brain and nerves · Nerve cells that slowly stop working
🎓 Learn more

What it is

degenerative change that occurs in individuals with Alzheimer's disease, such as amyloid plaques, cerebral amyloid angiopathy, neurofibrillary tangles, neuronal loss or synaptic loss

From the Open Targets disease record ↗

🧠 Brain and nerves: In neurodegenerative diseases, nerve cells in the brain or spinal cord stop working and die over time - affecting memory (Alzheimer's disease), movement (Parkinson's disease) or muscles (ALS).

❓ Why it happens

  • Proteins fold the wrong way and clump together inside or between nerve cells - amyloid and tau in Alzheimer's disease, alpha-synuclein in Parkinson's disease.
  • Inflammation, some genes (such as APOE4) and, above all, age raise the risk.

🫀 What it does to the body

  • As connections between nerve cells are lost, memory, thinking, movement or speech fade.
  • The changes start years - often decades - before the first symptoms.

🧱 Why it is hard to cure

  • Most medicines cannot easily pass the blood-brain barrier that protects the brain.
  • By the time symptoms appear, many nerve cells are already lost, and they do not grow back.
  • Many drug trials have failed, partly because the diseases are found late.

🚀 What research is trying now

  • Antibodies that clear amyloid and modestly slow early Alzheimer's disease (approved in some countries).
  • Blood tests that detect Alzheimer's changes years earlier.
  • Gene-targeted medicines, such as one approved in the US for an inherited form of ALS.

General information about brain and nerves, reviewed by people; it does not describe any one person. Below: the evidence for Alzheimer's disease neuropathologic change itself.

🤖

AI briefing

Where the science on Alzheimer's disease neuropathologic change stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands — every claim cited. It is shared with everyone who opens Alzheimer's disease neuropathologic change.

🎯

Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
NECTIN2 nectin cell adhesion molecule 2PROTACantibody🧊 AlphaFold structure ↗ 0.06
TOMM40 translocase of outer mitochondrial membrane 40PROTACsmall molecule🧊 AlphaFold structure ↗ 0.03
TARDBP TAR DNA binding proteinPROTAC🧊 AlphaFold structure ↗ 0.01
APOE apolipoprotein EPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.00
MAPT microtubule associated protein tauPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.00
SNCA synuclein alphaPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.00
C9orf72 C9orf72-SMCR8 complex subunitPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.00
GRN granulin precursorPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.00

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

💊

Drugs and candidates

Every medicine linked to Alzheimer's disease neuropathologic change, by how far it has got

No drugs recorded yet.

🧪

Recruiting trials

Worldwide, open to new patients now

No recruiting trials found.

Search more trials →
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy