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🗺️ Disease Atlas · Psychiatric disorder

early-onset Alzheimers disease

A rare form of Alzheimer's disease, occurring before the age of 65.

🔔 Follow weekly
🧬16genes / proteins with evidence
💊0drugs and clinical candidates
🧪12+recruiting trials worldwide
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Understand early-onset Alzheimers disease

Brain and nerves · Nerve cells that slowly stop working
🎓 Learn more

What it is

Dementia is a loss of mental functions that is severe enough to affect your daily life and activities. These functions include:

Memory

Language skills

From MedlinePlus: Dementia (US National Library of Medicine) ↗

🧠 Brain and nerves: In neurodegenerative diseases, nerve cells in the brain or spinal cord stop working and die over time - affecting memory (Alzheimer's disease), movement (Parkinson's disease) or muscles (ALS).

❓ Why it happens

  • Proteins fold the wrong way and clump together inside or between nerve cells - amyloid and tau in Alzheimer's disease, alpha-synuclein in Parkinson's disease.
  • Inflammation, some genes (such as APOE4) and, above all, age raise the risk.

🫀 What it does to the body

  • As connections between nerve cells are lost, memory, thinking, movement or speech fade.
  • The changes start years - often decades - before the first symptoms.

🧱 Why it is hard to cure

  • Most medicines cannot easily pass the blood-brain barrier that protects the brain.
  • By the time symptoms appear, many nerve cells are already lost, and they do not grow back.
  • Many drug trials have failed, partly because the diseases are found late.

🚀 What research is trying now

  • Antibodies that clear amyloid and modestly slow early Alzheimer's disease (approved in some countries).
  • Blood tests that detect Alzheimer's changes years earlier.
  • Gene-targeted medicines, such as one approved in the US for an inherited form of ALS.

General information about brain and nerves, reviewed by people; it does not describe any one person. Below: the evidence for early-onset Alzheimers disease itself.

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AI briefing

Where the science on early-onset Alzheimers disease stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands — every claim cited. It is shared with everyone who opens early-onset Alzheimers disease.

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Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
APOE apolipoprotein EPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.31
APOC1 apolipoprotein C1PROTACantibody🧊 AlphaFold structure ↗ 0.10
APOC2 apolipoprotein C2PROTACantibody🧊 AlphaFold structure ↗ 0.09
APOC4 apolipoprotein C4antibody🧊 AlphaFold structure ↗ 0.07
PSEN1 presenilin 1PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.01
PSEN2 presenilin 2PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.01
APP amyloid beta precursor proteinPROTACantibodyothersmall molecule🧊 AlphaFold structure ↗ 0.01
VEGFA vascular endothelial growth factor APROTACantibodyothersmall molecule🧊 AlphaFold structure ↗ 0.00
NCSTN nicastrinPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.00
ACHE acetylcholinesterase (Yt blood group)PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.00
PRNP prion protein (Kanno blood group)PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.00
ITPRIP inositol 1,4,5-trisphosphate receptor interacting proteinPROTACantibody🧊 AlphaFold structure ↗ 0.00
ITPR1 inositol 1,4,5-trisphosphate receptor type 1PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.00
HTT huntingtinPROTACsmall molecule🧊 AlphaFold structure ↗ 0.00
CYCS cytochrome c, somaticPROTACsmall molecule🧊 AlphaFold structure ↗ 0.00

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

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Drugs and candidates

Every medicine linked to early-onset Alzheimers disease, by how far it has got

No drugs recorded yet.

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Recruiting trials

Worldwide, open to new patients now
Neuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's DiseaseNCT06688968 · NA · 📍 MontpellierLecanemab for Early Onset Familial Alzheimer's DiseaseNCT06883019 · n/a · 📍 BeijingMIMA Pilot Study: MIcrostructure of the Medial Temporal Lobe in Early Alzheimer's DiseaseNCT06099587 · NA · 📍 RennesDonepezil Versus Non-drug Treatment in Alzheimer's Disease.NCT04661280 · Phase 3 · 📍 ParisA Multifocal tDCS-EEG Protocol for Improving Symptoms of Mild Cognitive Impairment and Early DementiaNCT06668610 · NA · 📍 CasertaMolecular and Structural Imaging in Alzheimer's Disease: A Longitudinal StudyNCT02740634 · NA · 📍 RochesterLifestyle Interventions for the Treatment of Early Onset Alzheimer's Disease StudyNCT05573490 · NA · 📍 IndianapolisDevelopment of a Database to Investigate Digital and Blood-Based Biomarkers and Their Relationship to Tau and…NCT06584357 · n/a · 📍 AtlantisChronic Treatment of Alzheimer's Disease by Gamma Light and Sound TherapyNCT05655195 · NA · 📍 CambridgeA Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL628 in Participant…NCT07328451 · Phase 1 · 📍 's-HertogenboschStudy of ARO-MAPT-SC in Healthy Participants and Participants With Early Alzheimer's DiseaseNCT07221344 · Phase 1, Phase 2 · 📍 East YorkA Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD…NCT05552157 · Phase 2, Phase 3 · 📍 Birmingham Search more trials →
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AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy