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๐Ÿ—บ๏ธ Disease Atlas ยท Phenotype

Camptocormia

An abnormal forward-flexed posture e.g. forward flexion of the spine, which is noticeable when standing or walking but disappears when lying down. It is becoming an increasingly recognized feature of Parkinson's disease and dystonic disorders.

๐Ÿ”” Follow weekly
๐Ÿงฌ22genes / proteins with evidence
๐Ÿ’Š0drugs and clinical candidates
๐Ÿงช2recruiting trials worldwide
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Understand Camptocormia

Every other disease ยท Genes, environment and time
๐ŸŽ“ Learn more

What it is

An abnormal forward-flexed posture e.g. forward flexion of the spine, which is noticeable when standing or walking but disappears when lying down. It is becoming an increasingly recognized feature of Parkinson's disease and dystonic disorders.

From the Open Targets disease record โ†—

๐Ÿ”ฌ Every other disease: Most diseases come from a mix of the genes we inherit, the environment and way we live, and the passing of time.

โ“ Why it happens

  • Genes can make a person more or less likely to get a disease.
  • Environment and lifestyle - infections, diet, smoking, pollution, activity - push the risk up or down.
  • Errors build up in the body over the years, which is why many diseases are more common with age.

๐Ÿซ€ What it does to the body

  • Each disease affects the body in its own way; the summary above explains this one.

๐Ÿงฑ Why it is hard to cure

  • The biology is often only partly understood.
  • A medicine has to be both effective and safe, and proving that in clinical trials takes years.

๐Ÿš€ What research is trying now

  • Studying which genes are linked to the disease - AI Cure shows them below, ranked by evidence.
  • Testing whether medicines approved for other diseases could help.

General information about every other disease, reviewed by people; it does not describe any one person. Below: the evidence for Camptocormia itself.

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AI briefing

Where the science on Camptocormia stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands โ€” every claim cited. It is shared with everyone who opens Camptocormia.

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Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
RRM2B ribonucleotide reductase regulatory TP53 inducible subunit M2BPROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.33
MYH7 myosin heavy chain 7PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.33
CAPN3 calpain 3PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.02
POLG2 DNA polymerase gamma 2, accessory subunitPROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.02
SLC6A3 solute carrier family 6 member 3PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.01
GAD1 glutamate decarboxylase 1PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.01
PYGM glycogen phosphorylase, muscle associatedPROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.01
MUSK muscle associated receptor tyrosine kinasePROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.00
PABPN1 poly(A) binding protein nuclear 1PROTAC๐ŸงŠ AlphaFold structure โ†— 0.00
RYR1 ryanodine receptor 1PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.00
ACHE acetylcholinesterase (Yt blood group)PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.00
PANK1 pantothenate kinase 1PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.00
SLC30A9 solute carrier family 30 member 9PROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.00
APP amyloid beta precursor proteinPROTACantibodyothersmall molecule๐ŸงŠ AlphaFold structure โ†— 0.00
TOR1A torsin family 1 member APROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.00

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

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Drugs and candidates

Every medicine linked to Camptocormia, by how far it has got

No drugs recorded yet.

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AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy