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🗺️ Disease Atlas · Gastrointestinal disease

gastric cancer

A primary or metastatic malignant neoplasm involving the stomach.

🔔 Follow weekly
🧬14594genes / proteins with evidence
💊375drugs and clinical candidates
🧪12+recruiting trials worldwide
✅11approved
📈63phase 3
🧬

Understand gastric cancer

Cancer · Cells that grow out of control
🎓 Learn more

What it is

Have had a Helicobacter pylori infection

Have had stomach inflammation

Are a man

From MedlinePlus: Stomach Cancer (US National Library of Medicine) ↗

🧬 Cancer: Cancer is a group of diseases in which some of the body's cells grow and divide without control, and can spread to other parts of the body.

❓ Why it happens

  • Changes (mutations) build up in the genes that tell a cell when to grow, divide and die.
  • Most of these changes happen during life: tobacco, too much sun, alcohol, some infections (such as HPV and hepatitis B and C), radiation, obesity and ageing all raise the risk.
  • Some people inherit a faulty gene that raises their risk, such as BRCA1 or BRCA2.

🫀 What it does to the body

  • Cancer cells form a lump (tumour) that can press on or invade nearby organs.
  • They can travel through the blood or lymph to start new tumours elsewhere (metastasis).
  • Blood cancers crowd out healthy blood cells in the bone marrow.

🧱 Why it is hard to cure

  • Every cancer is different, even between two people with the same type - and inside one tumour.
  • Cancer cells keep changing, so they can learn to resist a medicine that worked at first.
  • Cancer cells are the body's own cells, so killing them without harming healthy cells is hard.
  • Many cancers cause no symptoms until they have spread, and a new medicine often takes more than ten years to go from the lab to patients.

🚀 What research is trying now

  • Targeted medicines against the exact gene change in a tumour (for example EGFR, ALK or KRAS).
  • Immunotherapy that helps the immune system recognise cancer, including CAR-T cell therapy.
  • Personalised cancer vaccines built from each tumour's mutations, now in late trials.
  • Blood tests that look for tumour DNA to find cancer earlier, and AI to read scans and slides.

General information about cancer, reviewed by people; it does not describe any one person. Below: the evidence for gastric cancer itself.

🤖

AI briefing

Where the science on gastric cancer stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands — every claim cited. It is shared with everyone who opens gastric cancer.

🎯

Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
CDH1 cadherin 1PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.84
ERBB2 erb-b2 receptor tyrosine kinase 2PROTACantibodyothersmall molecule🧊 AlphaFold structure ↗ 0.81
APC APC regulator of Wnt signaling pathwayPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.81
KRAS KRas proto-oncogene, GTPasePROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.81
TP53 tumor protein p53PROTACothersmall molecule🧊 AlphaFold structure ↗ 0.78
FGFR2 fibroblast growth factor receptor 2PROTACantibodyothersmall molecule🧊 AlphaFold structure ↗ 0.77
ATM ATM serine/threonine kinasePROTACsmall molecule🧊 AlphaFold structure ↗ 0.74
MUTYH mutY DNA glycosylasePROTACsmall molecule🧊 AlphaFold structure ↗ 0.72
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.71
KDR kinase insert domain receptorPROTACantibodyothersmall molecule🧊 AlphaFold structure ↗ 0.69
ARID1A AT-rich interaction domain 1APROTAC🧊 AlphaFold structure ↗ 0.69
BRCA2 BRCA2 DNA repair associatedPROTACsmall molecule🧊 AlphaFold structure ↗ 0.67
BRCA1 BRCA1 DNA repair associatedPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.67
MSH6 mutS homolog 6PROTACsmall molecule🧊 AlphaFold structure ↗ 0.67
NF1 neurofibromin 1PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.66

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

💊

Drugs and candidates

Every medicine linked to gastric cancer, by how far it has got
Approved · 11
Anamorelin HydrochlorideGhrelin receptor agonistApproved
Esomeprazole MagnesiumPotassium-transporting ATPase inhibitorApproved
GimeracilDihydropyrimidine dehydrogenase inhibitorApproved
LeniolisibPI3-kinase p110-delta subunit inhibitorApproved
NivolumabProgrammed cell death protein 1 inhibitorApproved
RamucirumabVascular endothelial growth factor receptor 2 inhibitorApproved
Show all 11
TebentafuspMelanocyte protein PMEL binding agentApproved
TegafurThymidylate synthase inhibitorApproved
TrastuzumabReceptor protein-tyrosine kinase erbB-2 inhibitorApproved
Vonoprazan FumaratePotassium-transporting ATPase inhibitorApproved
ZolbetuximabClaudin-18 binding agentApproved
In phase 2 / 3 · 20
AdebrelimabProgrammed cell death 1 ligand 1 inhibitorPhase 3
Ascorbic AcidPhase 3
AtezolizumabProgrammed cell death 1 ligand 1 inhibitorPhase 3
BemarituzumabFibroblast growth factor receptor 2 inhibitor; Low affinity immunoglobulin gamma Fc regio…Phase 3
BevacizumabVascular endothelial growth factor A inhibitorPhase 3
CafelkibartPhase 3
Show all 20
CamrelizumabProgrammed cell death protein 1 antagonistPhase 3
CapecitabineThymidylate synthase inhibitorPhase 3
CatumaxomabT cell surface glycoprotein CD3 cross-linking agent; Epithelial cell adhesion molecule cr…Phase 3
CisplatinPhase 3
DocetaxelTubulin inhibitorPhase 3
DoxifluridineThymidylate synthase inhibitorPhase 3
DoxorubicinDNA topoisomerase II alpha inhibitorPhase 3
DurvalumabProgrammed cell death 1 ligand 1 inhibitorPhase 3
Endostatin, N-Terminal-MggshhhhhPhase 3
EpinephrineAdrenergic receptor agonistPhase 3
EpirubicinPhase 3
Epirubicin HydrochloridePhase 3
Epoetin AlfaErythropoietin receptor agonistPhase 3
EtoposideDNA topoisomerase II inhibitorPhase 3
Early trials · 20
AfuresertibSerine/threonine-protein kinase AKT inhibitorPhase 1/2
AldesleukinInterleukin-2 receptor agonistPhase 1/2
AlpelisibPI3-kinase p110-alpha subunit inhibitorPhase 1/2
AzacitidineDNA (cytosine-5)-methyltransferase 3A inhibitor; DNA (cytosine-5)-methyltransferase 1 inh…Phase 1/2
Azd-8186PI3-kinase p110-beta subunit inhibitor; PI3-kinase p110-delta subunit inhibitorPhase 1/2
BafisontamabHepatocyte growth factor receptor inhibitor; Epidermal growth factor receptor erbB1 inhib…Phase 1/2
Show all 20
BempegaldesleukinPhase 1/2
BexmarilimabPhase 1/2
Bintrafusp AlfaProgrammed cell death 1 ligand 1 binding agent; Transforming growth factor beta binding a…Phase 1/2
Bms-986148Phase 1/2
Bt-5528Phase 1/2
CemiplimabProgrammed cell death protein 1 inhibitorPhase 1/2
CetrelimabProgrammed cell death protein 1 inhibitorPhase 1/2
Chembl569766Phase 1/2
Cm-4307Phase 1/2
CobimetinibDual specificity mitogen-activated protein kinase kinase 1 inhibitor; Dual specificity mi…Phase 1/2
CyclophosphamidePhase 1/2
DaratumumabLymphocyte differentiation antigen CD38 inhibitorPhase 1/2
DecitabineDNA (cytosine-5)-methyltransferase 3A inhibitor; DNA (cytosine-5)-methyltransferase 1 inh…Phase 1/2
Enfortumab VedotinNectin-4 binding agent; Tubulin inhibitorPhase 1/2
🧪

Recruiting trials

Worldwide, open to new patients now
Neoadjuvant Immunotherapy Plus Chemotherapy in Borrmann Type 4 and Large Type 3 Gastric CancerNCT06451211 · Phase 2 · 📍 GuangzhouA Cohort Study on the Safety of Laparoscopic Resection of 5cm or Larger Gastric Gastrointestinal Stromal Tumo…NCT05938309 · n/a · 📍 FuzhouFeasibility of the LUM Imaging System for Detection of Gastrointestinal CancersNCT02584244 · Phase 1, Phase 2 · 📍 BostonLaparoscopic Gastrectomy With D2 Lymphadenectomy Combined With Hyperthermic Intraperitoneal Chemotherapy (HIP…NCT05871099 · Phase 3 · 📍 QingdaoPHASE II EVALUATION OF CYTOREDUCTION SURGERY AND HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY (CRS/HIPEC) IN GAS…NCT07178808 · Phase 2 · 📍 GilbertRadical Surgery Versus Non-Surgery in Gastric Cancer Patients With Peritoneal Metastasis After Successful Con…NCT07789184 · Phase 3 · 📍 BeijingDevelopment and Validation of a Risk Prediction Model for Gastric Retention in Patients Undergoing Sedated Ga…NCT07104214 · n/a · 📍 HangzhouPrediction of Neoadjuvant Chemotherapy Efficacy in Locally Advanced Gastric CancerNCT05140746 · NA · 📍 ShanghaiNab-Paclitaxel PIPAC in Combination With Paclitaxel and Ramucirumab for the Treatment of Stomach Cancer With …NCT06675136 · Phase 1 · 📍 DuarteA Phase I Interventional Open-label, Non-randomized Dose-escalation Trial to Evaluate the Safety, Tolerabilit…NCT07593820 · Phase 1 · 📍 BarcelonaNeoadjuvant of Sintilimab Combined Weekly Metronomic Chemotherapy (PLOF) for Resectable Locally Advanced Gast…NCT06054906 · Phase 2 · 📍 ShanghaiA Study of PF-08046054/SGN-PDL1V in Advanced Solid TumorsNCT05208762 · Phase 1 · 📍 Birmingham Search more trials →
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AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy