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Female reproductive organ cancer: the latest breakthroughs

Everything that changed in the last year, from three public sources: phase 3 trials that posted their results, papers in the leading medical and cancer journals, and US drug labels that were updated. Refreshed every week.

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What changed

Written by AI from the evidence below, every point cited

AI reads the results, papers and label updates below and explains what changed and why it matters, citing each source. It is shared with everyone.

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Phase 3 results posted

The large trials that decide new standard treatments · ClinicalTrials.gov
Relacorilant in Combination With Nab-Paclitaxel in Advanced, Platinum-Resistant, High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian-Tube CancerNCT05257408 · results posted 2026-09-25 · Corcept Therapeutics · 381 people · tests Relacorilant 150 mg, Nab-paclitaxel 80 mg/m^2, Nab-paclitaxel 100 mg/m^2 Durvalumab Treatment in Combination With Chemotherapy and Bevacizumab, Followed by Maintenance Durvalumab, Bevacizumab and Olaparib Treatment in Advanced Ovarian Cancer PatientsNCT03737643 · results posted 2026-06-09 · AstraZeneca · 1407 people · tests Bevacizumab, Durvalumab, Olaparib, Placebo olaparib Alpelisib Plus Olaparib in Platinum-resistant/Refractory, High-grade Serous Ovarian Cancer, With no Germline BRCA Mutation DetectedNCT04729387 · results posted 2026-06-04 · Novartis Pharmaceuticals · 358 people · tests Alpelisib, Olaparib, Paclitaxel, Pegylated liposomal doxorubicin (PLD) Study of the Safety and Contraceptive Efficacy of Relugolix Combination Therapy in Women With Uterine Fibroids or Endometriosis Who Are at Risk for PregnancyNCT04756037 · results posted 2026-05-13 · Sumitomo Pharma Switzerland GmbH · 1164 people · tests Relugolix Combination Therapy Immunobridging Study of 9- Valent Human Papillomavirus (9vHPV) Vaccine (V503) in Chinese Females 9 to 45 Years of Age (V503-024)NCT03903562 · results posted 2026-04-06 · Merck Sharp & Dohme LLC · 1990 people · tests V503 Pembrolizumab/Placebo Plus Paclitaxel With or Without Bevacizumab for Platinum-resistant Recurrent Ovarian Cancer (MK-3475-B96/KEYNOTE-B96/ENGOT-ov65).NCT05116189 · results posted 2026-03-09 · Merck Sharp & Dohme LLC · 643 people · tests Pembrolizumab, Paclitaxel, Bevacizumab, Placebo for pembrolizumab Study of Chemoradiotherapy With or Without Pembrolizumab (MK-3475) For The Treatment of Locally Advanced Cervical Cancer (MK-3475-A18/KEYNOTE-A18/ENGOT-cx11/GOG-3047)NCT04221945 · results posted 2026-01-05 · Merck Sharp & Dohme LLC · 1060 people · tests Pembrolizumab, Placebo for pembrolizumab, Cisplatin, External Beam Radiotherapy (EBRT) A Comparison of Platinum-based Therapy With TSR-042 and Niraparib Versus Standard of Care (SOC) Platinum-based Therapy as First-line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian CancerNCT03602859 · results posted 2025-12-31 · Tesaro, Inc. · 1400 people · tests Niraparib, Dostarlimab (TSR-042), Standard of care, Dostarlimab-Placebo Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial CancerNCT04269200 · results posted 2025-12-23 · AstraZeneca · 805 people · tests olaparib, durvalumab, durvalumab placebo, olaparib placebo
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In the leading journals

NEJM, Lancet, Nature, JCO, Cancer Cell and more · PubMed
Dalmelitinib Plus Aumolertinib in Advanced NSCLC Patients With EGFR-TKI Resistance and MET Amplification: A Randomized Phase 3 Trial.J Clin Oncol 2026 · PMID 42928710 Wing-tail coordination balances efficient cruising and maneuvering flight in an avian-inspired flapping robot.Nat Commun 2026 · PMID 42928387 Structural dynamics of substrate processing by the p97-Ufd1-Npl4-FAF1 machinery.Nat Commun 2026 · PMID 42928384 Cardiovascular resilience in centenarians.Nat Rev Cardiol 2026 · PMID 42928381 Molecular basis of DNA polymerase ζ's reverse transcriptase activity.Nat Commun 2026 · PMID 42928375 End-to-end design for full-color and large field-of-view computational holographic displays.Nat Commun 2026 · PMID 42928372 Record stack durability in industrial solid oxide steam electrolysis through operational control.Nat Commun 2026 · PMID 42928371 High-sensitivity deep shortwave infrared organic photodetectors enabled by selenium-integrated quinoidal molecular semiconductor.Nat Commun 2026 · PMID 42928368 Electrical signal transmission across electrolyte junctions separated by atomically-thin graphene.Nat Commun 2026 · PMID 42928364 Long-read RNA sequencing identifies non-coding isoform switching as a regulator of cell fate.Nat Commun 2026 · PMID 42928361 Approaching Landauer's limit in a single superconducting vortex memory bit.Nat Commun 2026 · PMID 42928359 Multimodal hydrogel modulation of extracellular vesicle cargo to arrest post-traumatic osteoarthritis in murine models.Nat Commun 2026 · PMID 42928352
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US drug labels updated

A label changes when a new use, dose or warning is approved · openFDA

No label updates found.

An update is not always a new approval — open the label to see what changed.

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