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Cervical cancer: the latest breakthroughs

Everything that changed in the last year, from three public sources: phase 3 trials that posted their results, papers in the leading medical and cancer journals, and US drug labels that were updated. Refreshed every week.

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What changed

Written by AI from the evidence below, every point cited

AI reads the results, papers and label updates below and explains what changed and why it matters, citing each source. It is shared with everyone.

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Phase 3 results posted

The large trials that decide new standard treatments · ClinicalTrials.gov
Impact of Applying a Bandage Skin Hydrogel on the Pains of the Head and Neck in Patients With Cancer of Head and Neck Treated With RadiotherapyNCT01520701 · results posted 2026-09-01 · Centre Francois Baclesse · 130 people · tests bandage skin Hydrotac®, Ialuset® Study to Evaluate the Safety, Tolerability and Efficacy of BF-200 ALA (Ameluz®) in the Field-directed Treatment of Actinic Keratosis (AK) on the Extremities and Neck/Trunk With Photodynamic Therapy (PDT) Using a RhodoLED LampNCT05662202 · results posted 2026-08-21 · Biofrontera Inc. · 172 people · tests BF-200 ALA and red light LED lamp, Vehicle and red light LED lamp Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Plus Chemotherapy in Participants With Metastatic Esophageal Carcinoma (MK-7902-014/E7080-G000-320/LEAP-014).NCT04949256 · results posted 2026-07-20 · Merck Sharp & Dohme LLC · 863 people · tests Pembrolizumab, Lenvatinib, Cisplatin, 5-FU A Study to Investigate Tislelizumab (BGB-A317) Versus Placebo in Combination With Concurrent Chemoradiotherapy in Participants With Localized Esophageal Squamous Cell CarcinomaNCT03957590 · results posted 2026-04-13 · BeiGene · 370 people · tests Tislelizumab, Placebo, Paclitaxel, Cisplatin A Study of Atezolizumab Plus Tiragolumab in Combination With Paclitaxel and Cisplatin Compared With Paclitaxel and Cisplatin as First-Line Treatment in Participants With Unresectable Locally Advanced, Unresectable Recurrent, or Metastatic Esophageal CarcinomaNCT04540211 · results posted 2026-04-09 · Hoffmann-La Roche · 461 people · tests Atezolizumab, Tiragolumab, Paclitaxel, Cisplatin A Study of Pralsetinib Versus Standard of Care for First-Line Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC)NCT04222972 · results posted 2026-03-05 · Hoffmann-La Roche · 223 people · tests Pralsetinib, Carboplatin, Cisplatin, Pemetrexed Phase III Xevinapant (Debio 1143) and Radiotherapy in Resected LA SCCHN, High Risk, Cisplatin-ineligible Participants (XRAY VISION)NCT05386550 · results posted 2026-02-19 · EMD Serono Research & Development Institute, Inc. · 166 people · tests Xevinapant, IMRT, Placebo Effectiveness Study of Human Papilloma Virus (HPV) Vaccines to Prevent Recurrence of Genital WartsNCT02750202 · results posted 2026-01-23 · University of Pretoria · 52 people · tests Quadrivalent HPV vaccine, Hepatitis B vaccine LUX-Head&Neck 3: Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer After Platinum Based ChemotherapyNCT01856478 · results posted 2026-01-12 · Boehringer Ingelheim · 340 people · tests Methotrexate, Afatinib Study of Chemoradiotherapy With or Without Pembrolizumab (MK-3475) For The Treatment of Locally Advanced Cervical Cancer (MK-3475-A18/KEYNOTE-A18/ENGOT-cx11/GOG-3047)NCT04221945 · results posted 2026-01-05 · Merck Sharp & Dohme LLC · 1060 people · tests Pembrolizumab, Placebo for pembrolizumab, Cisplatin, External Beam Radiotherapy (EBRT)
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In the leading journals

NEJM, Lancet, Nature, JCO, Cancer Cell and more · PubMed
Neoadjuvant nivolumab with or without visugromab in muscle-invasive bladder cancer: the phase 2a GDFATHER-NEO trial.Nat Med 2026 · PMID 42926233 Relatlimab plus nivolumab versus nivolumab for advanced melanoma: 5-year survival and biomarker analyses of the phase 3 RELATIVITY-047 tria…Nat Med 2026 · PMID 42926136 Pembrolizumab Plus Chemotherapy for HR+/HER2- PD-L1‒Positive Advanced Breast Cancer: Final Analysis of the Phase 3 KEYNOTE-B49 Study.Ann Oncol 2026 · PMID 42926111 Atirmociclib and fulvestrant for patients with HR+/HER2- advanced/metastatic breast cancer who progressed on a prior cyclin-dependent kinas…Ann Oncol 2026 · PMID 42926110 Adjuvant chemotherapy with cisplatin and gemcitabine compared to standard of care after curative intent resection of cholangiocarcinoma and…Ann Oncol 2026 · PMID 42926109 Overall survival from the phase III postMONARCH trial of abemaciclib plus fulvestrant versus placebo plus fulvestrant for HR+, HER2- advanc…Ann Oncol 2026 · PMID 42926108 A randomized Phase 1 study of telisotuzumab adizutecan (ABBV-400, Temab-A) in combination with bevacizumab versus trifluridine-tipiracil wi…Ann Oncol 2026 · PMID 42926107 Final results of nivolumab plus ipilimumab versus nivolumab or chemotherapy in microsatellite instability-high/mismatch repair-deficient me…Ann Oncol 2026 · PMID 42926106 Optimising late-line treatment administration in metastatic colorectal cancer: an even brighter SUNLIGHT.Lancet 2026 · PMID 42925881 14-day versus 28-day trifluridine-tipiracil plus bevacizumab for refractory metastatic colorectal cancer (PRABITAS): a pragmatic, multicent…Lancet 2026 · PMID 42925880 Q&A: Dan Landau on Somatic Evolution.Cancer Discov 2026 · PMID 42924526 ENZARAD (ANZUP 1303): Phase 3 Trial of Enzalutamide With Androgen Deprivation Therapy and Radiation Therapy in High-Risk Localized or Local…J Clin Oncol 2026 · PMID 42921729

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