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Chronic obstructive pulmonary disease: the latest breakthroughs

Everything that changed in the last year, from three public sources: phase 3 trials that posted their results, papers in the leading medical and cancer journals, and US drug labels that were updated. Refreshed every week.

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What changed

Written by AI from the evidence below, every point cited

AI reads the results, papers and label updates below and explains what changed and why it matters, citing each source. It is shared with everyone.

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Phase 3 results posted

The large trials that decide new standard treatments · ClinicalTrials.gov
Study to Assess the Efficacy, Safety, and Tolerability of SAR440340/REGN3500/Itepekimab in Chronic Obstructive Pulmonary Disease (COPD)NCT04701983 · results posted 2026-10-15 · Sanofi · 1127 people · tests Itepekimab SAR440340, Placebo Study to Assess the Efficacy, Safety, and Tolerability of SAR440340/REGN3500/Itepekimab in Chronic Obstructive Pulmonary Disease (COPD)NCT04751487 · results posted 2026-10-09 · Sanofi · 1234 people · tests Itepekimab SAR440340, Placebo A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Axatilimab Monotherapy in Japanese Participants With Recurrent or Refractory Active Chronic Graft-Versus-Host DiseaseNCT06263478 · results posted 2026-10-05 · Incyte Biosciences Japan GK · 21 people · tests INCA034176 A Study in Patients With Chronic Obstructive Pulmonary DiseaseNCT01245569 · results posted 2026-08-10 · Chiesi Farmaceutici S.p.A. · 419 people · tests Beclomethasone Dipropionate - Formoterol, Fluticasone - Salmeterol Tiotropium/Salmeterol Inhalation Powder in COPDNCT00668772 · results posted 2026-07-16 · Boehringer Ingelheim · 207 people · tests Tiotropium/Salmeterol, Salmeterol, Placebo, Tiotropium Efficacy of Fixed Combination of Beclometasone + Formoterol + Glycopyrrolate Versus Foster® in COPDNCT01917331 · results posted 2026-06-03 · Chiesi Farmaceutici S.p.A. · 1368 people · tests Beclometasone/Formoterol/Glycopyrrolate, Beclometasone/Formoterol Active Controlled Trial of CHF5993 Pressurized Metered-dose Inhaler ( pMDI) vs Symbicort®Turbuhaler® in Patients With Chronic Obstructive Pulmonary Disease ( COPD) (TRIVERSYTI)NCT03197818 · results posted 2026-05-27 · Chiesi Farmaceutici S.p.A. · 708 people · tests CHF 5993 100/6/12.5 µg, 160 µg budesonide + 4.5 µg formoterol fumarate Foster® pMDI (CHF 1535) Versus Symbicort® Turbohaler in COPD Patient (FORSYYN)NCT03888131 · results posted 2026-05-12 · Chiesi Farmaceutici S.p.A. · 750 people · tests CHF 1535 100/6 µg pMDI plus Symbicort® Turbohaler® Placebo, Symbicort® Turbohaler® plus C… A Pilot Study of the Use of 129Xe and 1H MRI to Measure the Modulation of Eosinophil-Related Inflammation by Mepolizumab In COPDNCT05138250 · results posted 2026-05-07 · Sheffield Teaching Hospitals NHS Foundation Trust · 31 people · tests Mepolizumab 100 MG Mepolizumab for COPD Hospital Eosinophilic Admissions Pragmatic TrialNCT04075331 · results posted 2026-04-24 · University of Leicester · 238 people · tests Mepolizumab, Placebo Functional Respiratory Imaging Study (DARWiIN)NCT04876677 · results posted 2026-04-09 · Chiesi Farmaceutici S.p.A. · 25 people · tests Beclomethasone dipropionate/Formoterol Fumarate/Glycopyrronium (BDP/FF/GB) Efficacy and Safety Study of Benralizumab in Patient With Eosinophilic Chronic Rhinosinusitis With Nasal Polyps (ORCHID)NCT04157335 · results posted 2026-02-19 · AstraZeneca · 295 people · tests Benralizumab 30 mg, Matched placebo
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In the leading journals

NEJM, Lancet, Nature, JCO, Cancer Cell and more · PubMed
Postoperative Pain Treatment After Pancreatic Surgery: A Systematic Review With Meta-Analyses and Trial Sequential Analyses.Eur J Pain 2026 · PMID 42944586 AdhE Regulates the Adaptation Ability of Streptococcus mutans to Oxidative Stress and Heat Stress.Mol Oral Microbiol 2026 · PMID 42944585 Sucrose Reshapes the Extracellular Protein-Peptide Landscape of Streptococcus mutans and Identifies Peptide Candidates With Antibiofilm Act…Mol Oral Microbiol 2026 · PMID 42944584 Is retinal vein occlusion an underrecognized paraneoplastic sentinel of lymphoma? A systematic review and meta-analysis of ocular-haematolo…Acta Ophthalmol 2026 · PMID 42944583 Discussing Future Treatment and Care in the ICU: Perspectives From Patients.Acta Anaesthesiol Scand 2027 · PMID 42944582 Seismic airgun array directivity from far-field measurements and modeling in the Gulf of Mexico.J Acoust Soc Am 2026 · PMID 42944581 A "functional anatomy" approach is valuable for both teaching and research.Anat Sci Educ 2026 · PMID 42944580 Unveiling the excited-state cycloaddition mechanism of crystalline 9-anthracenecarboxylic acid via transient absorption spectroscopy and th…Phys Chem Chem Phys 2026 · PMID 42944579 Models and components of investigation and bereavement care after sudden and unexpected child death: a scoping review.Cochrane Database Syst Rev 2026 · PMID 42944578 Reply to "Structured rehabilitation for terminal cancer: Aligning the evidence with the setting that funds it".Cancer 2026 · PMID 42944577 The electroanalytical wave against forever chemicals: molecularly imprinted electrochemical sensors for PFAS detection.Chem Commun (Camb) 2026 · PMID 42944576 Small-molecule-induced species redistribution drives amyloid remodeling along a conserved kinetic landscape.Nanoscale 2026 · PMID 42944575

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