AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

📰 Latest breakthroughs
🗺️ Disease Atlas · Disorder of visual system

glaucoma

Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.

🔔 Follow weekly
🧬5864genes / proteins with evidence
💊93drugs and clinical candidates
🧪12+recruiting trials worldwide
✅47approved
📈14phase 3
🔬

Understand glaucoma

Every other disease · Genes, environment and time
🎓 Learn more

What it is

Glaucoma is a group of diseases that can damage the optic nerve of one, or both, of your eyes. This can result in vision loss. There are different types of glaucoma, but the most common type is open-angle glaucoma. Other less common types include angle-closure glaucoma, and congenital glaucoma.

You may not have any symptoms of glaucoma. Regular eye exams by an eye care provider can check for glaucoma and other eye problems to help protect your vision. Treatments that lower eye pressure help slow the disease. Without treatment, glaucoma can eventually lead to blindness.

What causes glaucoma?

From MedlinePlus: Glaucoma (US National Library of Medicine) ↗

🔬 Every other disease: Most diseases come from a mix of the genes we inherit, the environment and way we live, and the passing of time.

❓ Why it happens

  • Genes can make a person more or less likely to get a disease.
  • Environment and lifestyle - infections, diet, smoking, pollution, activity - push the risk up or down.
  • Errors build up in the body over the years, which is why many diseases are more common with age.

🫀 What it does to the body

  • Each disease affects the body in its own way; the summary above explains this one.

🧱 Why it is hard to cure

  • The biology is often only partly understood.
  • A medicine has to be both effective and safe, and proving that in clinical trials takes years.

🚀 What research is trying now

  • Studying which genes are linked to the disease - AI Cure shows them below, ranked by evidence.
  • Testing whether medicines approved for other diseases could help.

General information about every other disease, reviewed by people; it does not describe any one person. Below: the evidence for glaucoma itself.

🤖

AI briefing

Where the science on glaucoma stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands — every claim cited. It is shared with everyone who opens glaucoma.

🎯

Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
MYOC myocilinPROTACantibody🧊 AlphaFold structure ↗ 0.91
CYP1B1 cytochrome P450 family 1 subfamily B member 1PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.88
LTBP2 latent transforming growth factor beta binding protein 2antibody🧊 AlphaFold structure ↗ 0.83
OPTN optineurinPROTACsmall molecule🧊 AlphaFold structure ↗ 0.77
ASB10 ankyrin repeat and SOCS box containing 10🧊 AlphaFold structure ↗ 0.76
TEK TEK receptor tyrosine kinasePROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.73
WDR36 WD repeat domain 36🧊 AlphaFold structure ↗ 0.71
EFEMP1 EGF-like fibulin extracellular matrix protein 1PROTACantibody🧊 AlphaFold structure ↗ 0.70
LOXL1 lysyl oxidase like 1PROTACantibody🧊 AlphaFold structure ↗ 0.66
ADRB2 adrenoceptor beta 2PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.63
TMCO1 transmembrane and coiled-coil domains 1PROTACantibody🧊 AlphaFold structure ↗ 0.62
CA2 carbonic anhydrase 2PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.62
ROCK2 Rho associated coiled-coil containing protein kinase 2PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.62
PTGFR prostaglandin F receptorPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.62
ROCK1 Rho associated coiled-coil containing protein kinase 1PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.61

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

💊

Drugs and candidates

Every medicine linked to glaucoma, by how far it has got
Approved · 20
AceclidineApproved
AcetazolamideCarbonic anhydrase I inhibitor; Carbonic anhydrase II inhibitorApproved
Acetazolamide SodiumCarbonic anhydrase I inhibitor; Carbonic anhydrase II inhibitorApproved
AcetylcholineMuscarinic acetylcholine receptor M3 agonistApproved
ApraclonidineAdrenergic receptor alpha-2 agonistApproved
BefunololApproved
Show all 20
BetaxololBeta-1 adrenergic receptor antagonistApproved
BimatoprostProstanoid FP receptor agonistApproved
BrimonidineAdrenergic receptor alpha-2 agonistApproved
Brimonidine TartrateAdrenergic receptor alpha-2 agonistApproved
BrinzolamideCarbonic anhydrase II inhibitorApproved
CarbacholMuscarinic acetylcholine receptor M3 agonistApproved
CarteololAdrenergic receptor beta antagonistApproved
Carteolol HydrochlorideAdrenergic receptor beta antagonistApproved
ClonidineAdrenergic receptor alpha-2 agonistApproved
DapiprazoleAlpha-1a adrenergic receptor antagonistApproved
DemecariumAcetylcholinesterase inhibitorApproved
DichlorphenamideCarbonic anhydrase I inhibitor; Carbonic anhydrase II inhibitorApproved
DipivefrinAdrenergic receptor agonistApproved
DorzolamideCarbonic anhydrase II inhibitorApproved
In phase 2 / 3 · 20
Betaxolol HydrochlorideBeta-1 adrenergic receptor antagonistPhase 3
BevacizumabVascular endothelial growth factor A inhibitorPhase 3
CiticolinePhase 3
FluorometholoneGlucocorticoid receptor agonistPhase 3
FluorouracilThymidylate synthase inhibitorPhase 3
KetorolacCyclooxygenase inhibitorPhase 3
Show all 20
LevobetaxololBeta-1 adrenergic receptor antagonistPhase 3
MemantineGlutamate [NMDA] receptor negative allosteric modulatorPhase 3
OfloxacinBacterial DNA gyrase inhibitorPhase 3
PrednisoloneGlucocorticoid receptor agonistPhase 3
Pyrroloquinoline QuinonePhase 3
SildenafilPhosphodiesterase 5A inhibitorPhase 3
TramiprosateAmyloid-beta A4 protein stabiliserPhase 3
Vitamin EPhase 3
NiacinamidePhase 2/3
PyruvatePhase 2/3
RanibizumabVascular endothelial growth factor A inhibitorPhase 2/3
Ciliary Neurotrophic FactorPhase 2
MetforminMitochondrial complex I (NADH dehydrogenase) inhibitor; Mitochondrial glycerol-3-phosphat…Phase 2
MoxaverinePhase 2
Early trials · 9
Ethacrynic AcidSodium-(potassium)-chloride cotransporter 2 inhibitorPhase 1/2
LuteinPhase 1/2
Sodium ChloridePhase 1/2
ZeaxanthinPhase 1/2
BamosiranBeta-2 adrenergic receptor mRNA RNAi inhibitorPhase 1
DecorinPhase 1
Show all 9
Insulin HumanInsulin receptor agonistPhase 1
OmeprazolePotassium-transporting ATPase inhibitorPhase 1
Fluocinolone AcetonideGlucocorticoid receptor agonistEarly phase 1
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy