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Psoriasis: the latest breakthroughs

Everything that changed in the last year, from three public sources: phase 3 trials that posted their results, papers in the leading medical and cancer journals, and US drug labels that were updated. Refreshed every week.

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What changed

Written by AI from the evidence below, every point cited

AI reads the results, papers and label updates below and explains what changed and why it matters, citing each source. It is shared with everyone.

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Phase 3 results posted

The large trials that decide new standard treatments · ClinicalTrials.gov
Open-Label Extension Trial of PDE4 Inhibition With Roflumilast for the Management of Plaque PsoriasisNCT04286607 · results posted 2026-09-09 · Arcutis Biotherapeutics, Inc. · 337 people · tests Topical roflumilast Bioequivalence Study of Two Treatments for the Treatment of Plaque PsoriasisNCT05763082 · results posted 2026-08-26 · Padagis LLC · 416 people · tests roflumilast cream 0.3%, Zoryve, Placebo A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis (ICONIC-ADVANCE 2)NCT06220604 · results posted 2026-06-25 · Janssen Research & Development, LLC · 731 people · tests JNJ-77242113, JNJ-77242113 Matching Placebo, Deucravacitinib, Deucravacitinib Matching Pl… A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque PsoriasisNCT06143878 · results posted 2026-06-25 · Janssen Research & Development, LLC · 774 people · tests JNJ-77242113, JNJ-77242113 Matching Placebo, Deucravacitinib, Deucravacitinib Matching Pl… A Study of JNJ-77242113 for the Treatment of Participants With Plaque Psoriasis Involving Special Areas (Scalp, Genital, and/or Palms of the Hands and the Soles of the Feet)NCT06095102 · results posted 2026-06-25 · Janssen Research & Development, LLC · 311 people · tests JNJ-77242113, Placebo Study of Guselkumab in Skin of Color Participants With Moderate-to-severe Plaque and/or Scalp PsoriasisNCT05272150 · results posted 2026-06-24 · Janssen Research & Development, LLC · 211 people · tests Guselkumab, Placebo A Study of JNJ-77242113 in Adolescent and Adult Participants With Moderate to Severe Plaque PsoriasisNCT06095115 · results posted 2026-06-01 · Janssen Research & Development, LLC · 684 people · tests JNJ-77242113, Placebo Study of Guselkumab Versus Placebo for the Treatment of Low Body Surface Area Moderate Plaque PsoriasisNCT06039189 · results posted 2026-05-01 · Janssen Research & Development, LLC · 338 people · tests Guselkumab, Placebo Study to Evaluate the Long-Term Safety and Efficacy of Imsidolimab (ANB019) in the Treatment of Subjects With GPPNCT05366855 · results posted 2026-03-27 · Vanda Pharmaceuticals · 42 people · tests Double-blind 200 mg imsidolimab, Placebo, Open-label 200 mg imsidolimab, Standard of Care… Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Subjects With GPPNCT05352893 · results posted 2026-03-17 · Vanda Pharmaceuticals · 45 people · tests 750 mg Imsidolimab, 300 mg Imsidolimab, Placebo A Study to Evaluate the Efficacy and Safety of Bimekizumab in Chinese Adult Study Participants With Moderate to Severe Plaque PsoriasisNCT06011733 · results posted 2026-02-20 · UCB Biopharma SRL · 133 people · tests Placebo, Bimekizumab A Study of Guselkumab in Participants With Active Psoriatic ArthritisNCT04882098 · results posted 2026-02-04 · Janssen Research & Development, LLC · 1054 people · tests Guselkumab, Placebo
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In the leading journals

NEJM, Lancet, Nature, JCO, Cancer Cell and more · PubMed

No papers found in the leading journals this year.

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AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy