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🗺️ Disease Atlas · Cancer or benign tumor

cervical carcinoma

A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma.

🔔 Follow weekly
🧬8566genes / proteins with evidence
💊69drugs and clinical candidates
🧪12+recruiting trials worldwide
✅15phase 3
📈35phase 2
🧬

Understand cervical carcinoma

Cancer · Cells that grow out of control
🎓 Learn more

What it is

Cervical cancer is cancer that starts in the cells of the cervix. The cervix is part of the female reproductive system. It is the lower, narrow end of the uterus (womb), which opens into the vagina (birth canal).

Cervical cancer usually develops slowly. Before cervical cells become cancer, they start to look abnormal. These cells are called "precancers." If they aren't destroyed or removed, they may become cancer cells that grow out of control and spread to other parts of your body.

Screening tests for cervical cancer can help find abnormal cells so you can get treatment to prevent cervical cancer. These tests can also find cervical cancer early when it's usually easier to treat.

From MedlinePlus: Cervical Cancer (US National Library of Medicine) ↗

🧬 Cancer: Cancer is a group of diseases in which some of the body's cells grow and divide without control, and can spread to other parts of the body.

❓ Why it happens

  • Changes (mutations) build up in the genes that tell a cell when to grow, divide and die.
  • Most of these changes happen during life: tobacco, too much sun, alcohol, some infections (such as HPV and hepatitis B and C), radiation, obesity and ageing all raise the risk.
  • Some people inherit a faulty gene that raises their risk, such as BRCA1 or BRCA2.

🫀 What it does to the body

  • Cancer cells form a lump (tumour) that can press on or invade nearby organs.
  • They can travel through the blood or lymph to start new tumours elsewhere (metastasis).
  • Blood cancers crowd out healthy blood cells in the bone marrow.

🧱 Why it is hard to cure

  • Every cancer is different, even between two people with the same type - and inside one tumour.
  • Cancer cells keep changing, so they can learn to resist a medicine that worked at first.
  • Cancer cells are the body's own cells, so killing them without harming healthy cells is hard.
  • Many cancers cause no symptoms until they have spread, and a new medicine often takes more than ten years to go from the lab to patients.

🚀 What research is trying now

  • Targeted medicines against the exact gene change in a tumour (for example EGFR, ALK or KRAS).
  • Immunotherapy that helps the immune system recognise cancer, including CAR-T cell therapy.
  • Personalised cancer vaccines built from each tumour's mutations, now in late trials.
  • Blood tests that look for tumour DNA to find cancer earlier, and AI to read scans and slides.

General information about cancer, reviewed by people; it does not describe any one person. Below: the evidence for cervical carcinoma itself.

🤖

AI briefing

Where the science on cervical carcinoma stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands — every claim cited. It is shared with everyone who opens cervical carcinoma.

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🎯

Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.65
FBXW7 F-box and WD repeat domain containing 7PROTACsmall molecule🧊 AlphaFold structure ↗ 0.62
STK11 serine/threonine kinase 11PROTACsmall molecule🧊 AlphaFold structure ↗ 0.61
EP300 EP300 lysine acetyltransferasePROTACsmall molecule🧊 AlphaFold structure ↗ 0.60
KMT2D lysine methyltransferase 2DPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.60
KMT2C lysine methyltransferase 2CPROTACsmall molecule🧊 AlphaFold structure ↗ 0.59
TP53 tumor protein p53PROTACothersmall molecule🧊 AlphaFold structure ↗ 0.54
KRAS KRas proto-oncogene, GTPasePROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.54
PTEN phosphatase and tensin homologPROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.53
NOTCH1 notch receptor 1PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.53
FAT1 FAT atypical cadherin 1PROTACantibody🧊 AlphaFold structure ↗ 0.53
FGFR2 fibroblast growth factor receptor 2PROTACantibodyothersmall molecule🧊 AlphaFold structure ↗ 0.53
ERBB2 erb-b2 receptor tyrosine kinase 2PROTACantibodyothersmall molecule🧊 AlphaFold structure ↗ 0.52
MAPK1 mitogen-activated protein kinase 1PROTACantibodysmall molecule🧊 AlphaFold structure ↗ 0.52
RB1 RB transcriptional corepressor 1PROTACsmall molecule🧊 AlphaFold structure ↗ 0.48

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

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Drugs and candidates

Every medicine linked to cervical carcinoma, by how far it has got
In phase 2 / 3 · 20
AtezolizumabProgrammed cell death 1 ligand 1 inhibitorPhase 3
BevacizumabVascular endothelial growth factor A inhibitorPhase 3
CarboplatinPhase 3
CatequentinibVascular endothelial growth factor receptor 2 inhibitor; Vascular endothelial growth fact…Phase 3
CisplatinPhase 3
Epoetin BetaErythropoietin receptor agonistPhase 3
Show all 20
FluorouracilThymidylate synthase inhibitorPhase 3
GemcitabineRibonucleoside-diphosphate reductase RR1 inhibitor; DNA polymerase (alpha/delta/epsilon) …Phase 3
NelfinavirHuman immunodeficiency virus type 1 protease inhibitorPhase 3
PaclitaxelTubulin inhibitorPhase 3
S1?Phase 3
TirapazaminePhase 3
TopotecanDNA topoisomerase I inhibitorPhase 3
Topotecan HydrochlorideDNA topoisomerase I inhibitorPhase 3
VinorelbineTubulin inhibitorPhase 3
AldesleukinInterleukin-2 receptor agonistPhase 2
Antineoplaston A10Phase 2
Arsenic TrioxideThioredoxin reductase 1 inhibitorPhase 2
BelotecanDNA topoisomerase I inhibitorPhase 2
Bryostatin 1Phase 2
Early trials · 17
AmifostinePhase 1/2
BemarituzumabFibroblast growth factor receptor 2 inhibitor; Low affinity immunoglobulin gamma Fc regio…Phase 1/2
Bizalimogene RalaplasmidPhase 1/2
CelecoxibCyclooxygenase-2 inhibitorPhase 1/2
EtigilimabT-cell immunoreceptor with Ig and ITIM domains inhibitorPhase 1/2
NivolumabProgrammed cell death protein 1 inhibitorPhase 1/2
Show all 17
Rocakinogene SifuplasmidPhase 1/2
EverolimusFK506-binding protein 1A inhibitorPhase 1
FenofibratePeroxisome proliferator-activated receptor alpha agonistPhase 1
InfigratinibFibroblast growth factor receptor inhibitorPhase 1
IrinotecanDNA topoisomerase I inhibitorPhase 1
MulnitorsenPhase 1
MurlentamabPhase 1
TalazoparibPoly [ADP-ribose] polymerase 2 inhibitor; Poly [ADP-ribose] polymerase-1 inhibitorPhase 1
TislelizumabProgrammed cell death protein 1 inhibitorPhase 1
TivantinibHepatocyte growth factor receptor inhibitorPhase 1
VeliparibPARP 1, 2 and 3 inhibitorPhase 1
🧪

Recruiting trials

Worldwide, open to new patients now
Preoperative Prediction of Lymph Node Metastasis in T1N0M0 Papillary Thyroid Carcinoma by Using Contrast-enha…NCT07357571 · n/a · 📍 Guangdong"Xijiang Project" Screening Cohort for NPCNCT06787456 · n/a · 📍 ZhuhaiReduced vs Conventional Dosage Intensity-modulated Radiotherapy for Chemotherapy-sensitive Stage II-III Nasop…NCT04448522 · Phase 3 · 📍 GuangzhouEstablishing a Tumor Registry for Patients With Neuroendocrine Carcinoma of the CervixNCT04723095 · n/a · 📍 HoustonImpact of Patient-Reported Outcomes for Symptom Monitoring in Patients Followed for Head and Neck Squamous Ce…NCT07190755 · NA · 📍 RouenThe Efficacy of Lymph Node Dissection for Stage IIICr of Cervical Cancer(CQGOG0103)NCT04555226 · NA · 📍 ChongqingNeoadjuvant Iparomlimab and Tuvonralimab Plus Chemotherapy-eclipse for Locally Advanced Cervical Cancer (NICE…NCT07055399 · Phase 2 · 📍 FuzhouPost-op T-DM1 in HER-2+ Salivary Gland CarcinomasNCT04620187 · Phase 2 · 📍 AtlantaClinical Study on the EBV CAR-T /TCR-T Cells in the Treatment of Nasopharyngeal CarcinomaNCT05587543 · EARLY Phase 1 · 📍 ShanghaiAn International Study on Pediatric Patients With Rare Tumors.NCT07072143 · n/a · 📍 PadovacDNA and Residual Disease After Chemoradiotherapy for Locally Advanced Head and Neck Squamous Cell CarcinomasNCT07178847 · NA · 📍 AurillacComparing Postoperative Adjuvant Cisplatin Concurrent Chemoradiotherapy With Adjuvant Radiotherapy Alone for …NCT07125755 · Phase 3 · 📍 Guangzhou Search more trials →
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Newest research

Latest papers on PubMed
Early Radiological Response Following Concurrent Chemoradiotherapy and Brachytherapy in Cervical Carcinoma: A Single-Centre Obser…Cureus 2026 · PMID 42928859Challenging diagnostic cases of peripheral ameloblastoma: a case series.J Med Case Rep 2026 · PMID 42928355Bridging the gap: advanced chromatin biotechnologies for circadian epigenomic profiling in head and neck squamous cell carcinoma.Clin Epigenetics 2026 · PMID 42928351Plasmablastic non-Hodgkin's lymphoma: a case report and review of the literature.J Med Case Rep 2026 · PMID 42928269[Efficacy of immunotherapy combined with anti-angiogenesis therapy in patients with advanced NSCLC and identification of prognost…Zhonghua Zhong Liu Za Zhi 2026 · PMID 42927951Confirmed Myocarditis-Myositis Overlap Without Myasthenia Gravis: Evaluating for Triple M Syndrome Following Combined Enfortumab …Cureus 2026 · PMID 42927390RACIAL DISPARITIES IN HEAD AND NECK SQUAMOUS CELL CARCINOMA: CANCER STEM CELL PATHWAYS AS DRIVERS OF OUTCOME DIFFERENCES.Trans Am Clin Climatol Assoc 2026 · PMID 42927335Sentinel lymph node-guided modification of postoperative radiotherapy in oral tongue squamous cell carcinoma: a retrospective dos…Clin Transl Radiat Oncol 2027 · PMID 42927216 Ask a research question in the Hypothesis Lab →
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AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy