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Colorectal cancer: the latest breakthroughs

Everything that changed in the last year, from three public sources: phase 3 trials that posted their results, papers in the leading medical and cancer journals, and US drug labels that were updated. Refreshed every week.

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What changed

Written by AI from the evidence below, every point cited

AI reads the results, papers and label updates below and explains what changed and why it matters, citing each source. It is shared with everyone.

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Phase 3 results posted

The large trials that decide new standard treatments · ClinicalTrials.gov
A Study of Nivolumab-relatlimab Fixed-dose Combination Versus Regorafenib or TAS-102 in Participants With Later-lines of Metastatic Colorectal CancerNCT05328908 · results posted 2026-08-26 · Bristol-Myers Squibb · 769 people · tests Nivolumab-relatlimab FDC, Regorafenib, TAS-102 Sotorasib and Panitumumab Versus Investigator's Choice for Participants With Kirsten Rat Sarcoma (KRAS) p.G12C MutationNCT05198934 · results posted 2026-07-22 · Amgen · 160 people · tests Sotorasib, Panitumumab, Trifluridine and Tipiracil, Regorafenib Immunosurveillance for Metastatic Colorectal CancerNCT06509880 · results posted 2026-06-29 · MIPO Clinic · 187 people · tests Adenorine, Placebo, FOLFOX regimen A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal CancerNCT04607421 · results posted 2026-06-11 · Pfizer · 841 people · tests Encorafenib, Cetuximab, Oxaliplatin, Irinotecan Rectal Cancer And Pre-operative Induction Therapy Followed by Dedicated Operation. The RAPIDO TrialNCT01558921 · results posted 2026-05-01 · University Medical Center Groningen · 920 people · tests M1 scheme, standard long course chemoradiotherapy Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch RepairNCT02912559 · results posted 2026-04-14 · National Cancer Institute (NCI) · 712 people · tests Atezolizumab, Biospecimen Collection, Computed Tomography, Fluorouracil Adjuvant Low Dose Aspirin in Colorectal CancerNCT02647099 · results posted 2026-03-13 · Anna Martling · 626 people · tests Acetylsalicylic acid, Placebo Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal CancerNCT04094688 · results posted 2026-03-03 · Alliance for Clinical Trials in Oncology · 455 people · tests Bevacizumab, Oxaliplatin, Leucovorin Calcium, Fluorouracil Study of Romiplostim for Chemotherapy-induced Thrombocytopenia in Adult Subjects With Gastrointestinal, Pancreatic, or Colorectal CancerNCT03362177 · results posted 2026-02-11 · Amgen · 165 people · tests Romiplostim, Placebo Initial Attack on Latent Metastasis Using TAS-102 for ct DNA Identified Colorectal Cancer Patients After Curative ResectionNCT04457297 · results posted 2026-01-21 · National Cancer Center Hospital East · 243 people · tests trifluridine and tipiracil, Placebo
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In the leading journals

NEJM, Lancet, Nature, JCO, Cancer Cell and more · PubMed
ctDNA clearance and outcomes for resectable lung cancer from NeoCOAST-2.Nature 2026 · PMID 42927884 Clinical Complete Response with Dostarlimab Monotherapy in dMMR/MSI-H Locally Advanced Rectal Cancer: First Results from the Global AZUR-1 …Ann Oncol 2026 · PMID 42927858 From Diagnosis to Destruction: The Rise of Radioligand Therapeutics as Oncology's New Pillar.Ann Oncol 2026 · PMID 42927857 Pembrolizumab plus lenvatinib with belzutifan or quavonlimab as first-line therapy for advanced renal-cell carcinoma: randomized open-label…Ann Oncol 2026 · PMID 42927856 Final prespecified analysis of the phase 3 LITESPARK-011 study: belzutifan plus lenvatinib versus cabozantinib for advanced renal cell carc…Ann Oncol 2026 · PMID 42927855 Pembrolizumab with or without platinum-based chemotherapy as first-line treatment in advanced NSCLC expressing PD-L1 ≥50%: The PERSEE rando…Ann Oncol 2026 · PMID 42927854 A randomised phase III trial of adjuvant treatment intensification with mFOLFIRINOX versus mFOLFOX6 in high-risk stage III colon cancer: Re…Ann Oncol 2026 · PMID 42927853 Neoadjuvant short-course radiotherapy followed by camrelizumab and chemotherapy versus standard of care for locally advanced rectal cancer …Lancet Oncol 2026 · PMID 42927765 Neoadjuvant nivolumab with or without visugromab in muscle-invasive bladder cancer: the phase 2a GDFATHER-NEO trial.Nat Med 2026 · PMID 42926233 Relatlimab plus nivolumab versus nivolumab for advanced melanoma: 5-year survival and biomarker analyses of the phase 3 RELATIVITY-047 tria…Nat Med 2026 · PMID 42926136 Pembrolizumab Plus Chemotherapy for HR+/HER2- PD-L1‒Positive Advanced Breast Cancer: Final Analysis of the Phase 3 KEYNOTE-B49 Study.Ann Oncol 2026 · PMID 42926111 Atirmociclib and fulvestrant for patients with HR+/HER2- advanced/metastatic breast cancer who progressed on a prior cyclin-dependent kinas…Ann Oncol 2026 · PMID 42926110

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