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๐Ÿ“ฐ Latest breakthroughs
๐Ÿ—บ๏ธ Disease Atlas ยท Cancer or benign tumor

undifferentiated pancreatic carcinoma with osteoclast-like giant cells

A rare variant of undifferentiated pancreatic carcinoma characterized by the presence of non-neoplastic osteoclast-like giant cells.

๐Ÿ”” Follow weekly
๐Ÿงฌ23genes / proteins with evidence
๐Ÿ’Š0drugs and clinical candidates
๐Ÿงช0recruiting trials worldwide
๐Ÿงฌ

Understand undifferentiated pancreatic carcinoma with osteoclast-like giant cells

Cancer ยท Cells that grow out of control
๐ŸŽ“ Learn more

What it is

A rare variant of undifferentiated pancreatic carcinoma characterized by the presence of non-neoplastic osteoclast-like giant cells.

From the Open Targets disease record โ†—

๐Ÿงฌ Cancer: Cancer is a group of diseases in which some of the body's cells grow and divide without control, and can spread to other parts of the body.

โ“ Why it happens

  • Changes (mutations) build up in the genes that tell a cell when to grow, divide and die.
  • Most of these changes happen during life: tobacco, too much sun, alcohol, some infections (such as HPV and hepatitis B and C), radiation, obesity and ageing all raise the risk.
  • Some people inherit a faulty gene that raises their risk, such as BRCA1 or BRCA2.

๐Ÿซ€ What it does to the body

  • Cancer cells form a lump (tumour) that can press on or invade nearby organs.
  • They can travel through the blood or lymph to start new tumours elsewhere (metastasis).
  • Blood cancers crowd out healthy blood cells in the bone marrow.

๐Ÿงฑ Why it is hard to cure

  • Every cancer is different, even between two people with the same type - and inside one tumour.
  • Cancer cells keep changing, so they can learn to resist a medicine that worked at first.
  • Cancer cells are the body's own cells, so killing them without harming healthy cells is hard.
  • Many cancers cause no symptoms until they have spread, and a new medicine often takes more than ten years to go from the lab to patients.

๐Ÿš€ What research is trying now

  • Targeted medicines against the exact gene change in a tumour (for example EGFR, ALK or KRAS).
  • Immunotherapy that helps the immune system recognise cancer, including CAR-T cell therapy.
  • Personalised cancer vaccines built from each tumour's mutations, now in late trials.
  • Blood tests that look for tumour DNA to find cancer earlier, and AI to read scans and slides.

General information about cancer, reviewed by people; it does not describe any one person. Below: the evidence for undifferentiated pancreatic carcinoma with osteoclast-like giant cells itself.

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AI briefing

Where the science on undifferentiated pancreatic carcinoma with osteoclast-like giant cells stands, from the evidence on this page

AI reads the targets, drugs, trials and papers below and writes where the science stands โ€” every claim cited. It is shared with everyone who opens undifferentiated pancreatic carcinoma with osteoclast-like giant cells.

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Top targets

Genes and proteins ranked by Open Targets evidence (0-1)
KRAS KRas proto-oncogene, GTPasePROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.37
BRCA2 BRCA2 DNA repair associatedPROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.28
TP53 tumor protein p53PROTACothersmall molecule๐ŸงŠ AlphaFold structure โ†— 0.28
CDKN2A cyclin dependent kinase inhibitor 2A๐ŸงŠ AlphaFold structure โ†— 0.28
POLQ DNA polymerase thetaPROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.19
MAP3K13 mitogen-activated protein kinase kinase kinase 13PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.19
SMAD4 SMAD family member 4PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.19
TP63 tumor protein p63PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.19
CDH11 cadherin 11PROTACantibody๐ŸงŠ AlphaFold structure โ†— 0.19
KDM6A lysine demethylase 6APROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.19
PTEN phosphatase and tensin homologPROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.19
EXT2 exostosin glycosyltransferase 2PROTACantibodysmall molecule๐ŸงŠ AlphaFold structure โ†— 0.19
IDH2 isocitrate dehydrogenase (NADP(+)) 2PROTACsmall molecule๐ŸงŠ AlphaFold structure โ†— 0.19
BAP1 BRCA1 associated deubiquitinase 1PROTAC๐ŸงŠ AlphaFold structure โ†— 0.19

Green labels: what the target is known to be druggable by. The score combines genetics, somatic mutations, drugs, expression and literature.

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Drugs and candidates

Every medicine linked to undifferentiated pancreatic carcinoma with osteoclast-like giant cells, by how far it has got

No drugs recorded yet.

๐Ÿงช

Recruiting trials

Worldwide, open to new patients now

No recruiting trials found.

Search more trials โ†’
๐Ÿ›ก๏ธ

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy